IFN-gamma R beta Chain antibody (PE)
Reactivity: Mouse
ELISA (Detection), IP, Neut
Host: Hamster
Monoclonal
MOB-47
PE
1 image
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- Target
- IFN-gamma R beta Chain
- Reactivity
- Mouse
- Host
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Hamster
- Clonality
- Monoclonal
- Conjugate
- PE
- Application
- ELISA (Detection), Immunoprecipitation (IP), Neutralization (Neut)
- Purification
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
- Clone
- MOB-47
- Isotype
- IgG
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.2 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Protect from prolonged exposure to light. Do not freeze.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Target
- IFN-gamma R beta Chain
- Background
- IFN-γ receptor β chain is also known as IFN-γ AF-1. This 60-65 kD class II cytokine receptor pairs with CDw119 to form the IFN-γ receptor. CDw119 serves as the IFN-γ-binding chain and associates with the IFN-γ β chain which is required for receptor signaling. The extracellular portion of both the IFN-γ receptor α and β chains must be species matched. The IFN-γ receptor β chain is expressed at low levels on T and B cells, NK cells, monocytes/ macrophages, and fibroblasts. Binding of IFN-γ induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-γ initiates and regulates a variety of immune responses.
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