Histone Deacetylase 6 (HDAC6) (AA 1-16) antibody

Details for Product No. ABIN2668292
Antigen
  • HD6
  • Hd6
  • Hdac5
  • Sfc6
  • mHDA2
  • CG6170
  • DHDAC2
  • DmHDAC2
  • Dmel\\CG6170
  • HDAC
  • HDAC2
  • dHDAC2
  • dHDAC6
  • dmHDA404
  • hdac6
  • MGC53140
  • wu:fc31d02
  • dsim_GLEANR_17355
  • DsimGD17207
  • GD17207
  • HDAC6
  • ATHDA6
  • AXE1
  • HISTONE DEACETYLASE 6
  • MDC12.7
  • MDC12_7
  • RNA-MEDIATED TRANSCRIPTIONAL SILENCING 1
  • RPD3B
  • RTS1
  • SIL1
  • histone deacetylase 6
  • histone deacetylase 6
  • Histone deacetylase 6
  • histone deacetylase 6 L homeolog
  • GD17207 gene product from transcript GD17207-RB
  • Histone DeAcetylase
  • HDAC6
  • Hdac6
  • hdac6.L
  • hdac6
  • Dsim\HDAC6
  • PTRG_03035
  • HDA6
  • hda-6
Epitope
AA 1-16
37
30
27
6
5
4
4
4
3
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
259
134
69
20
6
6
3
3
3
3
1
1
Host
Rabbit
232
38
1
Clonality
Polyclonal
Conjugate
Un-conjugated
11
6
5
5
5
5
5
5
4
3
3
3
2
2
2
2
2
Application
Chromatin Immunoprecipitation (ChIP), Western Blotting (WB)
200
138
90
74
41
26
22
18
17
14
8
4
2
2
1
Options
Immunogen This HDAC6 antibody was raised against a synthetic peptide corresponding to amino acid residues 1-16 of human HDAC6.
Isotype IgG
Purification Affinity Purified
Antigen
Alternative Name HDAC6 (HDAC6 Antibody Abstract)
Background HDAC6 (Histone Deacetylase 6) is a member of the class IIb mammalian histone deacetylases (HDACs) involved in regulating chromatin structure during transcription. These enzymes catalyze the removal of acetyl groups from lysine residues of histones or many cellular proteins. Lysine N-ε-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in regulation of gene expression in various cellular functions. It consists of the transfer of an acetyl moiety from an acetyl coenzyme A to the ε-amino group of a lysine residue. In vivo, acetylation is controlled by the antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The HDACs are grouped into four classes, on the basis of similarity to yeast counterparts: HDAC class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC6, HDAC7, 9 and 10), class III (SIRT1-7) and class IV (HDAC11). HDAC6 is a unique enzyme that harbors a full duplication of its deacetylase homology region, which appears to contribute independently to the overall activity of HDAC6 protein. alpha-tubulin and HSP90 are two known substrates of HDAC6, playing an important role in cellular mechanisms related to the microtubule network and HSP90-dependent events. HDAC6 also participates in regulating expression of a group of genes involved in the remodeling of chromatin during cell differentiation.
Molecular Weight 134 kDa
Gene ID 10013
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 μg/μL
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Storage -80 °C
Storage Comment Antibodies in solution can be stored at -80 °C for 2 years.
Expiry Date 6 months
Supplier Images
Image no. 1 for anti-Histone Deacetylase 6 (HDAC6) (AA 1-16) antibody (ABIN2668292) HDAC6 pAb tested by Western blot. Detection of HDAC6 by Western blot. The analysis wa...
Product cited in: Ying, Zhang, Zhou, Qu, Wang, Liu, Lu, Zhu: "Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB." in: PLoS ONE, Vol. 7, Issue 11, pp. e48832, 2012 (PubMed).

Keedy, Archin, Gates, Espeseth, Hazuda, Margolis: "A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression." in: Journal of virology, Vol. 83, Issue 10, pp. 4749-56, 2009 (PubMed).

Imbriano, Gurtner, Cocchiarella, Di Agostino, Basile, Gostissa, Dobbelstein, Del Sal, Piaggio, Mantovani: "Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters." in: Molecular and cellular biology, Vol. 25, Issue 9, pp. 3737-51, 2005 (PubMed).

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