LGR5 antibody (AA 250-550)

Catalog No. ABIN2724679

Product Details anti-LGR5 Antibody

Target: LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))

Binding Specificity: AA 250-550

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This LGR5 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Immunogen: Human recombinant protein fragment corresponding to amino acids 250-550 of human LGR5 (NP_003658) produced in 293T Cell.

Clone: OTI2A2

Isotype: IgG1

Application Details

Application Notes: FC:1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

References for anti-LGR5 antibody (ABIN2724679)

Nakaoka, Saito, Shimamoto, Muramatsu, Kimura, Kanai, Saito: "Cluster microRNAs miR-194 and miR-215 suppress the tumorigenicity of intestinal tumor organoids." in: Cancer science, Vol. 108, Issue 4, pp. 678-684, (2017) (PubMed).

Zhang, Han, Wei, Fang, Wei: "RSPO2 enriches LGR5(+) spheroid colon cancer stem cells and promotes its metastasis by epithelial-mesenchymal transition." in: American journal of translational research, Vol. 8, Issue 2, pp. 354-64, (2016) (PubMed).

Schumacher, Aihara, Feng, Engevik, Shroyer, Ottemann, Worrell, Montrose, Shivdasani, Zavros: "The use of murine-derived fundic organoids in studies of gastric physiology." in: The Journal of physiology, Vol. 593, Issue 8, pp. 1809-27, (2015) (PubMed).

Yang, Wu, Zhao, Li, Shi, Xie, Jiang, Wang, Li, Zhang, Shuai, Wang, Tao: "B7-H1 enhances proliferation ability of gastric cancer stem-like cells as a receptor." in: Oncology letters, Vol. 9, Issue 4, pp. 1833-1838, (2015) (PubMed).

Parris, Williams: "A human colonic crypt culture system to study regulation of stem cell-driven tissue renewal and physiological function." in: Methods in molecular biology (Clifton, N.J.), Vol. 1212, pp. 141-61, (2015) (PubMed).

Fraveto, Cardinale, Bragazzi, Giuliante, De Rose, Grazi, Napoletano, Semeraro, Lustri, Costantini, Nevi, Di Matteo, Renzi, Carpino, Gaudio, Alvaro: "Sensitivity of Human Intrahepatic Cholangiocarcinoma Subtypes to Chemotherapeutics and Molecular Targeted Agents: A Study on Primary Cell Cultures." in: PLoS ONE, Vol. 10, Issue 11, pp. e0142124, (2015) (PubMed).

Target Details for LGR5

Target: LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))

Alternative Name: LGR5 (LGR5 Products)

NCBI Accession: NM_003667

HGNC: 8549

Pathways: WNT Signaling