F11R antibody (F11 Receptor)

Details for Product anti-F11R Antibody No. ABIN2689190
Antigen
  • CD321
  • JAM
  • JAM1
  • JAMA
  • JCAM
  • KAT
  • PAM-1
  • 9130004G24
  • AA638916
  • ESTM33
  • JAM-1
  • JAM-A
  • Jcam
  • Jcam1
  • Ly106
  • Jam1
  • F11 receptor
  • F11R
  • F11r
Reactivity
Human
129
70
52
5
3
3
2
2
2
1
1
1
Host
Mouse
93
30
23
7
2
Clonality (Clone)
Monoclonal ()
Conjugate
This F11R antibody is un-conjugated
11
10
5
4
4
4
4
4
4
3
3
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
82
45
30
28
25
18
14
13
11
5
4
3
2
1
1
1
1
1
Options
Brand BD Pharmingen™
Clone M-Ab-F11
Isotype IgG1, kappa
Characteristics The M.Ab.F11 monoclonal antibody specifically binds to CD321 which is also known as JAM-1 (Junctional adhesion molecule 1), Junctional adhesion molecule A (JAM-A), and F11 Receptor (F11R). CD321 is a 32-35 kDa type I transmembrane glycoprotein that includes two extracellular immunoglobulin-like domains. CD321 is expressed on platelets, leucocytes, red blood cells, endothelial cells, epithelial cells, and various cell lines. CD321 functions as an adhesion receptor molecule on platelets. It also supports the tight junction formation between endothelial cells, where it may regulate the transendothelial migration of leucocytes, and epithelial cells. M.Ab.F11 is a stimulatory antibody that can induce morphological changes, granule secretion, and aggregation in human platelets. Flow cytometric analysis of human CD321 staining on platelets. Peripheral blood platelets were stained with either Purified Mouse Anti-Human CD321 (JAM-1) (Cat. No. 552147, solid line histogram) or Purified Mouse IgG1, κ Isotype Control (Cat. No. 555746, dashed line histogram), followed by second step staining with FITC Goat Anti-Mouse IgG/IgM (Cat. No. 555988).

BD Pharmingen™ Purified Mouse Anti-Human CD321 (JAM-1) - Purified - Clone M.Ab.F11 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Plasmids, Primers & others Plasmids, Primers & others F11R products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name CD321 JAM-1 (F11R Antibody Abstract)
Background Synonyms: JAM-1, Platelet F11 receptor, F11R, JAM-A, PAM-1
Pathways Cell-Cell Junction Organization
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.
Product cited in: Florian, Sonneck, Czerny, Hennersdorf, Hauswirth, Bühring, Valent: "Detection of novel leukocyte differentiation antigens on basophils and mast cells by HLDA8 antibodies." in: Allergy, Vol. 61, Issue 9, pp. 1054-62, 2006 (PubMed).

Horváth, Drbel, Angelisová, Hilgert, Horejsí: "Non-lineage antigens: section report." in: Cellular immunology, Vol. 236, Issue 1-2, pp. 42-7, 2005 (PubMed).

Babinska, Kedees, Athar, Sobocki, Sobocka, Ahmed, Ehrlich, Hussain, Kornecki: "Two regions of the human platelet F11-receptor (F11R) are critical for platelet aggregation, potentiation and adhesion." in: Thrombosis and haemostasis, Vol. 87, Issue 4, pp. 712-21, 2002 (PubMed).

Sobocka, Sobocki, Banerjee, Weiss, Rushbrook, Norin, Hartwig, Salifu, Markell, Babinska, Ehrlich, Kornecki: "Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation." in: Blood, Vol. 95, Issue 8, pp. 2600-9, 2000 (PubMed).

Kornecki, Walkowiak, Naik, Ehrlich: "Activation of human platelets by a stimulatory monoclonal antibody." in: The Journal of biological chemistry, Vol. 265, Issue 17, pp. 10042-8, 1990 (PubMed).

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