ZFYVE9 antibody (AA 71-170) (Alexa Fluor 647)

Catalog No. ABIN2690275

Product Details anti-ZFYVE9 Antibody (Alexa Fluor 647)

Target: ZFYVE9 (Zinc Finger, FYVE Domain Containing 9 (ZFYVE9))

Binding Specificity: AA 71-170

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZFYVE9 antibody is conjugated to Alexa Fluor 647

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SARA

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ZFYVE9

Target: ZFYVE9 (Zinc Finger, FYVE Domain Containing 9 (ZFYVE9))

Alternative Name: SARA (ZFYVE9 Products)

Synonyms: CG15667 antibody, Dmel\\CG15667 antibody, SARA antibody, dSARA antibody, sara antibody, NSP antibody, Madhip antibody, SMADIP antibody, E030027L17 antibody, MADHIP antibody, Smad anchor for receptor activation antibody, zinc finger, FYVE domain containing 9 antibody, zinc finger FYVE-type containing 9 antibody, Sara antibody, Zfyve9 antibody, ZFYVE9 antibody

Background:

Synonyms: NSP, SARA, MADHIP, SMADIP, PPP1R173, Zinc finger FYVE domain-containing protein 9, Mothers against decapentaplegic homolog-interacting protein, Madh-interacting protein, Novel serine protease, Receptor activation anchor, hSARA, Smad anchor for receptor activation, ZFYVE9

Background: Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.

Gene ID: 9372

UniProt: O95405

Pathways: Protein targeting to Nucleus