Myeloperoxidase antibody (MPO) (PE)

Details for Product anti-MPO Antibody No. ABIN2749160
Antigen
  • mKIAA4033
  • MPO
  • LOC100335032
  • POX2'
  • XPOX2'
  • mpo
  • mpo-A
  • pmr-1
  • pmr1
  • pox2
  • xpox2
  • myeloperoxidase
  • myeloperoxidase L homeolog
  • MPO
  • Mpo
  • LOC100335032
  • mpo.L
Reactivity
Human
451
95
79
7
6
4
2
2
2
1
1
1
1
Host
Mouse
270
225
7
2
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Myeloperoxidase antibody is conjugated to PE
56
47
27
22
19
17
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), ELISA
315
260
117
79
57
53
43
40
39
20
17
15
13
9
4
4
3
2
2
1
1
Options
Immunogen Human myeloperoxidase
Clone MPO421-8B2
Isotype IgG1
Specificity The mouse monoclonal antibody MPO421-8B2 recognizes human myeloperoxidase, a heme protein present in myeloblasts, neutrophils and monocytes. It is a marker of acute myelogenous leukemias and acute lymphoblastic leukemias.
Cross-Reactivity (Details) Human
Plasmids, Primers & others Plasmids, Primers & others Myeloperoxidase products on genomics-online (e.g. as negative or positive controls)
Antigen
Background Myeloperoxidase (MPO) is a heme enzyme that is localized in azurophilic (primary) granules of myeloid cells and its synthesis occurs at an early stage of differentiation. The mature myeloperoxidase is a tetramer composed of two light (12 kDa) and two heavy (60 kDa) chains. This enzyme uses hydrogen peroxide to oxidize numerous substrates, including serotonin, melatonin or chloride, to produce reactive free radicals that contribute to immune reactions of myeloid cells against pathogens. Myeloperoxidase functions not only in host defense by mediating efficient microbial killing but also can contribute to progressive tissue damage in chronic inflammatory states such as atherosclerosis or acute pancreatitis.
Pathways Chromatin Binding
Application Notes The reagent is designed for Flow Cytometry analysis of human blood cells using 10 μ,l reagent / 100 μ,l of whole blood or 106 cells in a suspension.The content of a vial (1 ml) is sufficient for 100 tests.
Comment

The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

Restrictions For Research Use only
Buffer The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
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