GADD45GIP1 antibody (Middle Region)

Catalog No. ABIN2789108

Product Details anti-GADD45GIP1 Antibody

Target: GADD45GIP1 (Growth Arrest and DNA-Damage-Inducible, gamma Interacting Protein 1 (GADD45GIP1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Rabbit, Cow, Horse, Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GADD45GIP1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SLRVKQLAEE QKRREREQHI AECMAKMPQM IVNWQQQQRE NWEKAQADKE

Predicted Reactivity: Cow: 90%, Dog: 90%, Guinea Pig: 85%, Horse: 90%, Human: 100%, Mouse: 90%, Pig: 92%, Rabbit: 85%, Rat: 92%, Yeast: 91%

Characteristics: This is a rabbit polyclonal antibody against GADD45GIP1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 222 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GADD45GIP1

Target: GADD45GIP1 (Growth Arrest and DNA-Damage-Inducible, gamma Interacting Protein 1 (GADD45GIP1))

Alternative Name: GADD45GIP1 (GADD45GIP1 Products)

Synonyms: si:dkey-194e13.6 antibody, CKBBP2 antibody, CRIF1 antibody, PLINP antibody, PLINP-1 antibody, PRG6 antibody, Plinp1 antibody, 2310040G17Rik antibody, AI425883 antibody, Crif1 antibody, growth arrest and DNA-damage-inducible, gamma interacting protein 1 antibody, GADD45G interacting protein 1 antibody, gadd45gip1 antibody, GADD45GIP1 antibody, Gadd45gip1 antibody

Background: GADD45GIP1 acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. GADD45GIP1 acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. GADD45GIP1 may be involved in the hormone-mediated regulation of NR4A1 transcriptional activity.
Alias Symbols: CKBBP2, CRIF1, MGC4667, MGC4758, PLINP-1, PRG6, Plinp1
Protein Interaction Partner: FBXW11, UBC, LIN28A, EXOSC4, UPF2, TMEM177, MRPL11, MRPL14, TSR1, PTRH2, EIF3C, TAP1, MRPL12, APP, COPS5, HNRNPA1, NFE2L2, ICT1, AR, IKBKG, GADD45G, GADD45B, NR4A1, GADD45A, CSNK2B,
Protein Size: 222

Molecular Weight: 24 kDa

Gene ID: 90480

NCBI Accession: NM_052850, NP_443082

UniProt: Q8TAE8