CTDP1 antibody (C-Term)

Catalog No. ABIN2790245

Product Details anti-CTDP1 Antibody

Target: CTDP1 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Phosphatase, Subunit 1 (CTDP1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Dog, Horse, Pig, Rabbit, Rat, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTDP1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AHAPDKEPEL GGQEEGERDG LCGLGNGCAD RKEAETESQN SELSGVTAGE

Predicted Reactivity: Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against CTDP1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CTDP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 867 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CTDP1

Target: CTDP1 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Phosphatase, Subunit 1 (CTDP1))

Alternative Name: CTDP1 (CTDP1 Products)

Background: This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: CCFDN, FCP1
Protein Interaction Partner: UBC, CDK9, UPP1, PPP2CA, PPP1CA, POLR2A, POLR2C, GRK5, ELP2, ELP3, SUMO2, PRKDC, CDK8, CDK7, INTS8, MED15, MED4, INTS6, INTS1, INTS7, MED16, MED6, MED24, MED7, MED26, MED17, MED23, MED14, MED1, MED8, MED25, INTS3, POLR2J, ERH, POLR2B, STK38, PRMT5, HIST1H
Protein Size: 867

Molecular Weight: 93 kDa

Gene ID: 9150

NCBI Accession: NM_048368, NP_430255

UniProt: Q9Y5B0