DAND5 antibody (C-Term)

Catalog No. ABIN2790536

Product Details anti-DAND5 Antibody

Target: DAND5 (DAN Domain Family, Member 5 (DAND5))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DAND5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: YIPGSDPTPL VLCNSCMPAR KRWAPVVLWC LTGSSASRRR VKISTMLIEG

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against DAND5. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human DAND5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 189 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DAND5

Target: DAND5 (DAN Domain Family, Member 5 (DAND5))

Alternative Name: DAND5 (DAND5 Products)

Background: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.
Alias Symbols: CER2, CERL2, CKTSF1B3, COCO, CRL2, DANTE, GREM3, MGC126849, SP1
Protein Size: 189

Molecular Weight: 21 kDa

Gene ID: 199699

NCBI Accession: NM_152654, NP_689867

UniProt: Q8N907