TRADD antibody (Middle Region)

Catalog No. ABIN2792121

This anti-TRADD antibody is a Rabbit Polyclonal antibody detecting TRADD in WB. Suitable for Human, Dog and Horse.

Quick Overview for TRADD antibody (Middle Region) (ABIN2792121)

Target: TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))

Reactivity: Human, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRADD antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRADD Antibody

Binding Specificity: Middle Region

Sequence: YEQAFQLLRR FVQAEGRRAT LQRLVEALEE NELTSLAEDL LGLTDPNGGL

Predicted Reactivity: Dog: 76%, Horse: 76%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against TRADD. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TRADD

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 312 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRADD

Target: TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))

Alternative Name: TRADD

Background: TRADD is the adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: Hs.89862, MGC11078
Protein Interaction Partner: FADD, UBC, TNF, RIPK1, TNFRSF1A, ZMYND11, TOMM70A, PDLIM7, LRRK2, OPTN, TRADD, TRAF2, TRAF1, TNFRSF1B, GFRA1, CHUK, FAS, DAB2IP, EDAR, CDKN2A, TRIP12, LMP1, CASP8, SH3KBP1, USP2, TNFRSF25, PPP2R1A, TRPC4AP, HIPK2, TNFRSF21, CNTRL, TNFRSF10B, TNFRSF10A, BC
Protein Size: 312

Molecular Weight: 34 kDa

Gene ID: 8717

NCBI Accession: NM_003789, NP_003780

UniProt: Q15628

Pathways: NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Hepatitis C