TEFM antibody (Transcription Elongation Factor, Mitochondrial) (Alexa Fluor 594) Primary Antibody
Human, Mouse, Rat
This TEFM antibody is conjugated to Alexa Fluor 594
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Purified by Protein A.
- KLH conjugated synthetic peptide derived from human C17orf42
- Application Notes
- IF(IHC-P) 1:50-200
- For Research Use only
- 1 μg/μL
- Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 4 °C
- Storage Comment
- Store at 4°C
- Expiry Date
- 12 months
- Alternative Name
- C17orf42 (TEFM Antibody Abstract)
- C17orf42, TEFM, zgc:153083, RGD1306595, transcription elongation factor, mitochondrial, TEFM, tefm, Tefm
C17orf42 is a 360 amino acid protein that exists as two alternatively spliced isoforms and is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.
Synonyms: Chromosome 17 open reading frame 42, FLJ22729, Hypothetical protein LOC79736, MGC24674, UPF0629 protein C17orf42, TEFM_HUMAN.
- Gene ID