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TEFM antibody (Transcription Elongation Factor, Mitochondrial) (Alexa Fluor 594) Primary Antibody

TEFM Reactivity: Human, Mouse, Rat IF (p) Host: Rabbit Polyclonal Alexa Fluor 594
Catalog No. ABIN2810602
$442.20
Plus shipping costs $45.00
100 μL
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Delivery in 11 to 16 Business Days
  • Target
    TEFM
    Reactivity
    Human, Mouse, Rat
    • 19
    • 15
    • 15
    • 2
    • 1
    • 1
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This TEFM antibody is conjugated to Alexa Fluor 594
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    • 12
    • 8
    • 3
    • 1
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human C17orf42
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store at 4°C
    Expiry Date
    12 months
  • Target
    TEFM
    Alternative Name
    C17orf42 (TEFM Antibody Abstract)
    Synonyms
    C17orf42, TEFM, zgc:153083, RGD1306595, transcription elongation factor, mitochondrial, TEFM, tefm, Tefm
    Background

    C17orf42 is a 360 amino acid protein that exists as two alternatively spliced isoforms and is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

    Synonyms: Chromosome 17 open reading frame 42, FLJ22729, Hypothetical protein LOC79736, MGC24674, UPF0629 protein C17orf42, TEFM_HUMAN.

    Gene ID
    79736
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