gGT6 antibody (AA 351-450) (Alexa Fluor 594)

Catalog No. ABIN2813717

Product Details anti-gGT6 Antibody

Target: gGT6 (gamma-Glutamyltransferase 6 (gGT6))

Binding Specificity: AA 351-450

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This gGT6 antibody is conjugated to Alexa Fluor 594

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GGT6

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C/-80 °C

Storage Comment: Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles

Expiry Date: 12 months

Target Details for gGT6

Target: gGT6 (gamma-Glutamyltransferase 6 (gGT6))

Alternative Name: GGT6 (gGT6 Products)

Synonyms: 9030405D14Rik antibody, AI427679 antibody, AW490214 antibody, gamma-glutamyltransferase 6 antibody, gamma-glutamyl transferase 6 antibody, GGT6 antibody, Ggt6 antibody

Background:

Gamma-glutamyltranspeptidase (GGT) acts as a glutathionase and catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This enzyme is located on the outer surface of the cell membrane and is widely distributed in mammalian tissues involved in absorption and secretion. In humans, hepatic GGT activity is elevated in some liver diseases. GGT1 is released into the bloodstream after liver damage, and an elevated level of the enzyme may be a useful early sign of hepatocellular carcinoma. GGT5 converts leukotriene C4 to leukotriene D4, it does not, however, convert synthetic substrates that are commonly used to assay GGT. In human serum and in human tissues, there is a marked heterogeneity in GGT, but this heterogeneity can be attributed to different glycosylation of the same peptide rather than to the products of different genes. Belonging to the gamma-glutamyltranspeptidase family, GGT6 (gamma-glutamyltransferase 6), is a 493 amino acid single-pass type II membrane protein that cleaves glutathione conjugates. GGT6 exists as two alternatively spliced isoforms.

Subcellular location: Cell membrane

Synonyms: Gamma glutamyltransferase 6 homolog, Gamma glutamyltranspeptidase 6, GGT 6.