Neuroketals antibody

Catalog No. ABIN285871

This Goat Polyclonal antibody specifically detects in IHC, ELISA and WB. It exhibits reactivity toward Mammalian.

Quick Overview for Neuroketals antibody (ABIN285871)

Target: Neuroketals

Reactivity: Mammalian

Host: Goat

Clonality: Polyclonal

Application: Immunohistochemistry (IHC), ELISA, Western Blotting (WB)

Product Details

Immunogen: Neuroketal antibody was raised in goat using neuroketal-Conjugate as the immunogen.

Application Details

Application Notes: ELISA: >1:4,000, IHC-P: >1:200, WB: >1:2,000
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Neat serum, with 0.1 % NaN3 as a preservative.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.

Target Details

Target: Neuroketals

Alternative Name: Neuroketal

Background: Neuroketals and neuroprostanes are a class of compounds that result from the oxidation of docosahexenoic acid (DHA), which is enriched in the brain and retina, especially the synaptic membranes and retina. DHA is a membrane polyunsaturated fatty acid that is especially vulnerable to free radical attack because hydrogen radicals easily remove its double bonds. The DHA is oxidized to isoprostane-like compounds called neuroprostanes, which can dehydrate to form highly reactive A4/J4 neuroprostanes . Neuroprostanes can also undergo rearrangement to form D- and E-ring neuroprostanes. These reactive neuroprostanes are called neuroketals because DHA is so concentrated in the nervous system.