RASA1 antibody (RAS P21 Protein Activator (GTPase Activating Protein) 1)

Details for Product anti-RASA1 Antibody No. ABIN3022298
Antigen
  • CG9209
  • D-RasGAP
  • Dmel\\CG9209
  • RAS-GAP
  • RasGAP
  • RasGap
  • rasGap
  • CM-AVM
  • CMAVM
  • GAP
  • PKWS
  • RASA
  • RASGAP
  • p120GAP
  • p120RASGAP
  • GAPX
  • Rasa
  • Gap
  • vacuolar peduncle
  • RAS p21 protein activator 1
  • vap
  • RASA1
  • Rasa1
Reactivity
Mouse (Murine), Rat (Rattus), Human
113
59
57
5
2
2
2
2
2
2
1
1
1
Host
Rabbit
92
20
2
1
Clonality
Polyclonal
Conjugate
This RASA1 antibody is un-conjugated
6
5
5
3
3
3
3
3
3
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
78
36
26
16
15
9
8
2
2
1
1
1
Options
Immunogen Recombinant protein of human RASA1
Isotype IgG
Purification Affinity purification
Plasmids, Primers & others Plasmids, Primers & others RASA1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name RASA1 (RASA1 Antibody Abstract)
Background The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]
Synonyms: GAP, PKWS, RASA, CMAVM, CM-AVM, RASGAP, p120GAP, p120RASGAP
Gene ID 5921
UniProt P20936
Pathways Regulation of Actin Filament Polymerization, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals
Application Notes Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze / thaw cycles
Storage -20 °C/-80 °C
Supplier Images
Image no. 1 for anti-RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) antibody (ABIN3022298) anti-RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) antibody
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