CCL4 antibody (Chemokine (C-C Motif) Ligand 4) Primary Antibody
CCL4
Reactivity: Human, Mouse, Rat
IHC, WB
Host: Rabbit
Polyclonal
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Catalog No. ABIN3022367
$589.88
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- Target
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Clonality
- Polyclonal
- Conjugate
- This CCL4 antibody is un-conjugated
- Application
- Immunohistochemistry (IHC), Western Blotting (WB)
- Purification
- Affinity purification
- Immunogen
- A synthetic peptide of human CCL4
- Isotype
- IgG
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- Application Notes
- Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid freeze / thaw cycles
- Storage
- -20 °C/-80 °C
-
- Target
- Alternative Name
- CCL4 (CCL4 Antibody Abstract)
- Background
- Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50 % homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta , MIP-2, MIP-3 alpha, MIP-3 beta , MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1 beta is more selective than MIP-1 alpha, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1 alpha is a more potent lymphocyte chemoattractant than MIP-1 beta and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1 alpha has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1 beta and RANTES. Recombinant human MIP-1 alpha acts as an inhibitor of different strains of HIV-1, HIV-2 and SIV infection in a dose-dependent manner.
Synonyms: ACT2, G-26, HC21, LAG1, LAG-1, MIP1B, SCYA2, SCYA4, MIP1B1, AT744.1, MIP-1-beta - Gene ID
- 6351
- UniProt
- P13236
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