CCL4 antibody (Chemokine (C-C Motif) Ligand 4)

Catalog No. ABIN3022367

Product Details anti-CCL4 Antibody

Target:

CCL4

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCL4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Purification: Affinity purification

Immunogen: A synthetic peptide of human CCL4

Isotype: IgG

Application Details

Application Notes: Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C/-80 °C

Target Details for CCL4

Target:

CCL4

Alternative Name: CCL4 (CCL4 Antibody Abstract)

Background: Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50 % homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta , MIP-2, MIP-3 alpha, MIP-3 beta , MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1 beta is more selective than MIP-1 alpha, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1 alpha is a more potent lymphocyte chemoattractant than MIP-1 beta and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1 alpha has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1 beta and RANTES. Recombinant human MIP-1 alpha acts as an inhibitor of different strains of HIV-1, HIV-2 and SIV infection in a dose-dependent manner.
Synonyms: ACT2, G-26, HC21, LAG1, LAG-1, MIP1B, SCYA2, SCYA4, MIP1B1, AT744.1, MIP-1-beta

Gene ID: 6351

UniProt: P13236