SDHA antibody (AA 385-664)

Catalog No. ABIN3023400

Product Details anti-SDHA Antibody

Target: SDHA (Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) (SDHA))

Binding Specificity: AA 385-664

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SDHA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: ETAMIFAGVD VTKEPIPVLP TVHYNMGGIP TNYKGQVLRH VNGQDQIVPG LYACGEAACA SVHGANRLGA NSLLDLVVFG RACALSIEES CRPGDKVPPI KPNAGEESVM NLDKLRFADG SIRTSELRLS MQKSMQNHAA VFRVGSVLQE GCGKISKLYG DLKHLKTFDR GMVWNTDLVE TLELQNLMLC ALQTIYGAEA RKESRGAHAR EDYKVRIDEY DYSKPIQGQQ KKPFEEHWRK HTLSYVDVGT GKVTLEYRPV IDKTLNEADC ATVPPAIRSY

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 385-664 of human SDHA (NP_004159.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:10 - 1:100

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-SDHA antibody (ABIN3023400)

Gillen, Brechbuhl, Yamamoto, Kline, Pillai, Hesselberth, Kabos: "Alternative Polyadenylation of PRELID1 Regulates Mitochondrial ROS Signaling and Cancer Outcomes." in: Molecular cancer research : MCR, Vol. 15, Issue 12, pp. 1741-1751, (2018) (PubMed).

Target Details for SDHA

Target: SDHA (Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) (SDHA))

Alternative Name: SDHA (SDHA Products)

Background: This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,SDHA,CMD1GG,FP,PGL5,SDH1,SDH2,SDHF,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Oxidative phosphorylation,Neuroscience,Neurodegenerative Diseases,SDHA

Molecular Weight: 56 kDa/67 kDa/72 kDa

Gene ID: 6389

UniProt: P31040