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PPP1R13L antibody (Isoform 1)

PPP1R13L Reactivity: Human, Mouse, Cow, Dog EIA, IF, IHC (p), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN303133
$739.20
Plus shipping costs $45.00
50 μg
Shipping to: United States
Available
  • Target See all PPP1R13L Antibodies
    PPP1R13L (Protein Phosphatase 1, Regulatory Subunit 13 Like (PPP1R13L))
    Binding Specificity
    • 16
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Isoform 1
    Reactivity
    • 51
    • 21
    • 17
    • 7
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Cow, Dog
    Host
    • 47
    • 4
    Rabbit
    Clonality
    • 49
    • 2
    Polyclonal
    Conjugate
    • 26
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PPP1R13L antibody is un-conjugated
    Application
    • 27
    • 14
    • 14
    • 14
    • 13
    • 10
    • 8
    • 8
    • 3
    • 3
    • 2
    • 2
    • 1
    Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Specificity
    ,Species:Human, Bovine, Dog and Mouse.
    Purification
    Immunoaffinity Chromatography.
    Immunogen
    Synthetic peptide corresponding to Amino Acids 780-797 of human iASPP (isoform 1) protein.
  • Application Notes
    Immunohistochemistry on Paraffin Sections (2.5 μg/mL). Immunofluorescence. Western Blot (1/1000-1/5000). ELISA (1/40000-1/160000).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.19 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide as preservative.
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody undiluted (in aliquots) at-20 °C. Dilute only prior to immediate use.
  • Target
    PPP1R13L (Protein Phosphatase 1, Regulatory Subunit 13 Like (PPP1R13L))
    Alternative Name
    PPP1R13L (PPP1R13L Products)
    Synonyms
    AV260376 antibody, IASPP antibody, Nkip1 antibody, wa3 antibody, zgc:113058 antibody, NKIP1 antibody, RAI antibody, RAI4 antibody, protein phosphatase 1, regulatory (inhibitor) subunit 13 like antibody, protein phosphatase 1, regulatory subunit 13 like antibody, protein phosphatase 1 regulatory subunit 13 like antibody, protein phosphatase 1 regulatory subunit 13 like L homeolog antibody, Ppp1r13l antibody, ppp1r13l antibody, PPP1R13L antibody, ppp1r13l.L antibody
    Background
    ASPP proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, the third member, iASPP, functionally inactivates p53. iASPP (also called protein phosphatase 1 regulatory (inhibitor) subunit 13 like protein, Inhibitor of ASPP protein, Protein iASPP, PPP1R13B-like protein and NFkB-interacting protein 1) plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. iASPP blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. This protein also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. iASPP is predominantly a cytoplasmic protein (isoform 1) but can also be found in the nucleus (isoform 2). iASPP is highly expressed in heart, placenta and prostate and is weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. The N-terminal region of isoform 1 is required for cytoplasmic localization. Defects in iASPP may be a cause of certain breast cancers and the protein is overexpressed in many patients suffering from breast carcinomas and expressing a wild-type p53/TP53 protein.Synonyms: IASPP, Inhibitor of ASPP protein, NFkB-interacting protein 1, NKIP1, PPP1R13B-like protein, PPP1R13BL, RAI, RelA-associated inhibitor
    Gene ID
    10848
    NCBI Accession
    NP_001135974
    UniProt
    Q8WUF5
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