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Patched 2 antibody (C-Term)

PTCH2 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3032167
$635.25
Plus shipping costs $45.00
100 μg
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  • Target See all Patched 2 (PTCH2) Antibodies
    Patched 2 (PTCH2)
    Binding Specificity
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 16
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 16
    • 1
    Rabbit
    Clonality
    • 16
    • 1
    Polyclonal
    Conjugate
    • 13
    • 2
    • 1
    • 1
    This Patched 2 antibody is un-conjugated
    Application
    • 12
    • 8
    • 5
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Purification
    Antigen affinity
    Immunogen
    An amino acid sequence from the C-terminus of human Patched 2 (WLHDKYDTTGENLRIPP) was used as the immunogen for this PTCH2 antibody.
    Isotype
    IgG
  • Application Notes
    The stated application concentrations are suggested starting amounts. Titration of the PTCH2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Storage
    -20 °C
    Storage Comment
    After reconstitution, the PTCH2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    Patched 2 (PTCH2)
    Alternative Name
    PTCH2 (Patched 2) (PTCH2 Products)
    Synonyms
    PTC2 antibody, ptc2 antibody, Ptch1 antibody, ptc-2 antibody, xptc-2 antibody, xptch-2 antibody, patched-2 antibody, ptch2 antibody, ptc-1 antibody, ptc1 antibody, ptch1 antibody, patched 2 antibody, patched 2 S homeolog antibody, patched 2 L homeolog antibody, PTCH2 antibody, Ptch2 antibody, ptch2.S antibody, ptch2.L antibody, ptch2 antibody
    Background
    PTCH2 (Patched 2), also known as PTC2, encodes a 1.203-amino acid putative transmembrane protein that is highly homologous to the PTCH product. The Patched-hedgehog signaling pathway is involved in establishing segment polarity and the anterior-posterior orientation of a number of developing appendages. The pathway is conserved from fly to vertebrates and has been implicated in a number of human neoplasms and developmental syndromes. Mutations in the human Patched gene are the basis of the nevoid basal cell carcinoma syndrome. With age, homozygous mutant male mice developed skin lesions consisting of alopecia and epidermal hyperplasia, suggesting a role for PTCH2 in adult epidermal homeostasis via Shh signaling.
    UniProt
    Q9Y6C5
    Pathways
    Hedgehog Signaling
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