Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

IFITM1 antibody (Interferon-Induced Transmembrane Protein 1) (AA 1-17) Primary Antibody

IFITM1 Reactivity: Human IHC (fro), IHC (p), WB Host: Rabbit Polyclonal
Pubmed (3)
Catalog No. ABIN3044336
$280.00
Plus shipping costs $45.00
100 μg
local_shipping Shipping to: United States
Delivery in 4 to 6 Business Days
  • Target
    Binding Specificity
    AA 1-17, N-Term
    Reactivity
    Human
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This IFITM1 antibody is un-conjugated
    Application
    Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for Interferon-induced transmembrane protein 1(IFITM1) detection. Tested with WB, IHC-P, IHC-F in Human.
    Sequence
    MHKEEHEVAV LGPPPST
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Interferon-induced transmembrane protein 1(IFITM1) detection. Tested with WB, IHC-P, IHC-F in Human.
    Gene Name: interferon induced transmembrane protein 1
    Protein Name: Interferon-induced transmembrane protein 1
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminus of human IFITM1(1-17aa MHKEEHEVAVLGPPPST).
    Isotype
    IgG
  • Target
    Alternative Name
    IFITM1 (IFITM1 Antibody Abstract)
    Background
    Interferon-induced Transmembrane Protein 1(IFITM1), also called Interferon-induced Protein 17(IFI17). IFITM1 activity is required for primordial germ cells(PGCs) transit from the mesoderm into the endoderm, and that it appears to act via a repulsive mechanism, such that PGCs avoid Ifitm1-expressing tissues. It is mapped to Chr.11 and belongs to the family of interferon-induced transmembrane proteins(Ifitm/mil/fragilis), which encodes cell surface proteins that may modulate cell adhesion and influence cell differentiation. Interferon-inducible membrane proteins of approximately 17 kDa have been suggested to play a role in the antiproliferative activity of interferons based on their pattern of induction in interferon-sensitive and -resistant cell lines and the ability of a membrane fraction enriched in 17- kDa proteins to inhibit cell growth.

    Synonyms: 9-27 antibody|CD 225 antibody|CD 225 antigen antibody|CD225 antibody|CD225 antigen antibody|Dispanin subfamily A member 2a antibody|DSPA2a antibody|IFI 17 antibody|IFI17 antibody|IFITM1 antibody|IFM1_HUMAN antibody|Interferon induced protein 17 antibody|interferon induced transmembrane protein 1(9-27) antibody|Interferon induced transmembrane protein 1 antibody|Interferon inducible protein 9-27 antibody|Interferon-induced protein 17 antibody|Interferon-induced transmembrane protein 1 antibody|Interferon-inducible protein 9-27 antibody|Leu 13 antibody|Leu 13 antigen antibody|Leu-13 antigen antibody|LEU13 antibody
    UniProt
    P13164
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Human
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Thimerosal (Merthiolate), Sodium azide
    Precaution of Use
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Ma, Zhang, Fu, Xia, Zhan, Li, Wang, Wu: "Wnt signaling may be activated in a subset of Peutz-Jeghers syndrome polyps closely correlating to LKB1 expression." in: Oncology reports, Vol. 23, Issue 6, pp. 1569-76, 2010 (PubMed).

    Xu, Yang, Hu: "Binding of IFITM1 enhances the inhibiting effect of caveolin-1 on ERK activation." in: Acta biochimica et biophysica Sinica, Vol. 41, Issue 6, pp. 488-94, 2009 (PubMed).

    Yang, Xu, Chen, Hu: "IFITM1 plays an essential role in the antiproliferative action of interferon-gamma." in: Oncogene, Vol. 26, Issue 4, pp. 594-603, 2007 (PubMed).

You are here:
help Support