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NOS1 antibody (Nitric Oxide Synthase 1, Neuronal) (C-Term) Primary Antibody

NOS1 Reactivity: Human, Mouse, Rat, Guinea Pig, Rabbit IHC, WB Host: Goat Polyclonal unconjugated
Catalog No. ABIN350524
$454.67
Plus shipping costs $45.00
500 μg
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Delivery in 7 to 8 Business Days
  • Target See all NOS1 Antibodies
    NOS1
    Binding Specificity
    • 30
    • 15
    • 15
    • 11
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 131
    • 98
    • 68
    • 15
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Guinea Pig, Rabbit
    Host
    • 139
    • 11
    • 8
    • 1
    • 1
    • 1
    Goat
    Clonality
    • 143
    • 18
    Polyclonal
    Conjugate
    • 78
    • 18
    • 10
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    This NOS1 antibody is un-conjugated
    Application
    • 97
    • 64
    • 42
    • 27
    • 26
    • 20
    • 18
    • 18
    • 17
    • 15
    • 11
    • 6
    • 6
    • 6
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB)
    Specificity
    Specific for NOS1.
    Immunogen
    A synthetic pentamer-peptide from the c-terminal region of human NOS1 conjugated to an immunogenic carrier protein was used as the antigen.
    Isotype
    IgG
  • Application Notes
    A concentration of 10-50 µg/ml is recommended.
    The optimal concentration should be determined by the end user.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
    Handling Advice
    Avoid freeze and thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Expiry Date
    12 months
  • Target
    NOS1
    Alternative Name
    NOS1 (NOS1 Products)
    Synonyms
    NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS, 2310005C01Rik, NO, NOS-I, Nos-1, nos, ihps1, nnos, nos1, nos1-A, nanos C2HC-type zinc finger 1, nitric oxide synthase 1, nitric oxide synthase 1, neuronal, nitric oxide synthase 1 (neuronal), nitric oxide synthase 1 L homeolog, NANOS1, NOS1, Nos1, nos1, nos1.L
    Background
    Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
    Catalytic activity: L-arginine + n NADPH + m O2 = citrulline + nitric oxide + n NADP+.
    Enzyme regulation: Stimulated by calcium/calmodulin. Inhibited by n-Nos-inhibiting protein (PIN) which may prevent the dimerization of the protein. Inhibited by NOSIP.
    Subcellular location: Cell membrane, sarcolemma, Peripheral membrane protein. Cell projection, dendritic spine. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines.
    Tissue specificity: Isoform N-NOS-1 is expressed in brain and colorectum. Found in the Auerbach's plexus of the enteric nervous system. Isoform PNNOS is expressed in the penis, urethra, prostate, and skeletal muscle, and coexists with the cerebellar nnos in the pelvic plexus, bladder and liver, and is detectable in the cerebellum. Also known as: BNOS, NOS type I, Neuronal NOS, N-NOS, nNOS, Constitutive NOS, NC-NOS, Nitric oxide synthase.
    Pathways
    Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction
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