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Sortilin 1 antibody (SORT1) (Cytoplasmic Domain) Primary Antibody

SORT1 Reactivity: Human IHC, WB Host: Rabbit Polyclonal
Catalog No. ABIN350865
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500 μg
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  • Target
    Binding Specificity
    Cytoplasmic Domain
    This Sortilin 1 antibody is un-conjugated
    Immunohistochemistry (IHC), Western Blotting (WB)
    Specific for Sortilin.
    A synthetic peptide from the cytoplasmic domain of human Sortilin (Neurotensin receptor 3, NTR3, Sort1) conjugated to an immunogenic carrier protein was used as the immunogen.
  • Application Notes
    A concentration of 10-50 µg/ml is recommended.
    The optimal concentration should be determined by the end user.
    Not yet tested in other applications.
    For Research Use only
  • Format
    Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
    Handling Advice
    Avoid freeze and thaw cycles.
    4 °C/-20 °C
    Storage Comment
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Expiry Date
    12 months
  • Target
    Alternative Name
    Sortilin (SORT1 Antibody Abstract)
    Function: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
    Subunit: Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP and GM2A, LPL, PSAP and SLC2A4. Forms a complex with NGFR which binds specifically to the precursor form of NGFB (proNGFB). Interacts with the precursor form of BDNF (proBDNF).
    Subcellular location: Membrane, Single-pass type I membrane protein. Note: Localized to membranes of the endosomes, Golgi stack, lysosomes and nucleus. Localization to the plasma membrane in adipocytes is enhanced by insulin. Localized to the endoplasmic reticulum and the plasma membrane. Also found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes.
    Tissue specificity: Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver. Also known as: Neurotensin receptor 3, NTR3, NT3, Glycoprotein 95, Gp95, 100 kDa NT receptor.
    Neurotrophin Signaling Pathway
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