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Sortilin 1 Products

(Sortilin 1 (SORT1))
This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes\; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p\; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins. [provided by RefSeq, Jul 2008].

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Featured Sortilin 1 Categories

Sortilin 1 Antibodies

High quality antibodies with extensive validation data.

Sortilin 1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Sortilin 1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Sortilin 1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Application IHC, WB
Validations
  • (6)
Cat. No. ABIN350866
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application IHC, WB
Validations
  • (6)
Cat. No. ABIN350869
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (5)
Cat. No. ABIN562759
Quantity 100 μg
Datasheet Datasheet

Recommended Sortilin 1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970373
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959642
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959643
Quantity 96 tests
Datasheet Datasheet

Recommended Sortilin 1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095533
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3135819
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3117619
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our Sortilin 1 products

Fleitas, Piñol-Ripoll, Marfull, Rocandio, Ferrer, Rampon, Egea, Espinet: "proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing." in: Molecular brain, Vol. 11, Issue 1, pp. 68, (2019) (PubMed).

Oh, Ahn, Kim, Kim, Moon, Lim, Park, Lim, Jang, Choi: "Circulating sortilin level as a potential biomarker for coronary atherosclerosis and diabetes mellitus." in: Cardiovascular diabetology, Vol. 16, Issue 1, pp. 92, (2018) (PubMed).

Zhou, Jiang, Griffith, Patrylo, Cai, Chu, Yan: "Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer's disease model mice and macaques." in: Alzheimer's research & therapy, Vol. 10, Issue 1, pp. 40, (2018) (PubMed).

Hagita, Rogers, Pham, Wen, Mlynarchik, Aikawa, Aikawa: "Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin." in: Scientific reports, Vol. 8, Issue 1, pp. 9006, (2018) (PubMed).

Paik, ONeil, Ng, Sun, Rubin: "Using intracellular markers to identify a novel set of surface markers for live cell purification from a heterogeneous hIPSC culture." in: Scientific reports, Vol. 8, Issue 1, pp. 804, (2018) (PubMed).

Campbell, Beug, Nickerson, Peng, Mazerolle, Bassett, Ringuette, Jama, Morales, Christ, Wallace: "Sortilin regulates sorting and secretion of Sonic hedgehog." in: Journal of cell science, Vol. 129, Issue 20, pp. 3832-3844, (2016) (PubMed).

Sánchez, Bergareche, Krebs, Gorostidi, Makarov, Ruiz-Martinez, Chorny, Lopez de Munain, Marti-Masso, Paisán-Ruiz: "SORT1 Mutation Resulting in Sortilin Deficiency and p75(NTR) Upregulation in a Family With Essential Tremor." in: ASN neuro, Vol. 7, Issue 4, (2015) (PubMed).

Ghaemimanesh, Bayat, Babaei, Ahmadian, Zarnani, Behmanesh, Jeddi-Tehrani, Rabbani: "Production and Characterization of a Novel Monoclonal Antibody Against Human Sortilin." in: Monoclonal antibodies in immunodiagnosis and immunotherapy, Vol. 34, Issue 6, pp. 390-5, (2015) (PubMed).

Butkinaree, Canuel, Essalmani, Poirier, Benjannet, Asselin, Roubtsova, Hamelin, Marcinkiewicz, Chamberland, Guillemot, Mayer, Sisodia, Jacob, Prat, Seidah: "Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other." in: The Journal of biological chemistry, Vol. 290, Issue 30, pp. 18609-20, (2015) (PubMed).

Lee, Almeida, Prudencio, Caulfield, Zhang, Tay, Bauer, Chew, Sasaguri, Jansen-West, Gendron, Stetler, Finch, Mackenzie, Rademakers, Gao, Petrucelli: "Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency." in: Human molecular genetics, Vol. 23, Issue 6, pp. 1467-78, (2014) (PubMed).

Synonyms and alternative names related to Sortilin 1

sortilin 1 (SORT1), sortilin (TP01_0016), sortilin (BBOV_I002730), sortilin 1 S homeolog (sort1.S), sortilin 1 (Sort1), sortilin 1a (sort1a), 19.m02079, 2900053A11Rik, AI852375, gp95, Gp95, ldlcq6, LDLCQ6, NT3, Nt3, Ntr3, Nts3, Ntsr3, SORT1, sort1, sortilin, zgc:85953

Protein level used designations for Sortilin 1

  • sortilin 1
  • sortilin
  • sortilin-like
  • 100 kDa NT receptor
  • NTR3
  • glycoprotein 95
  • neurotensin receptor 3
  • mNTR3
  • glycoprotein 110
  • gp110
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