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IRAK2 antibody (Interleukin-1 Receptor-Associated Kinase 2) Primary Antibody

IRAK2 Reactivity: Human IHC (p), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN372430
$580.80
Plus shipping costs $45.00
50 μg
local_shipping Shipping to: United States
Available
  • Target
    IRAK2
    Reactivity
    • 100
    • 24
    • 17
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 99
    • 6
    Rabbit
    Clonality
    • 92
    • 13
    Polyclonal
    Conjugate
    • 46
    • 9
    • 7
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This IRAK2 antibody is un-conjugated
    Application
    • 83
    • 62
    • 28
    • 14
    • 10
    • 9
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Specificity
    This antibody recognizes Interleukin 1 Receptor-Associated Kinase 2 (IRAK2).
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Protein G Chromatography.
    Immunogen
    Synthetic peptide of Human IRAK-2 - KLH conjugated.
    Isotype
    IgG
  • Application Notes
    Immunohistochemistry on Paraffin Sections: 10 μg/mL. Western blot: 1-3 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    PBS containing 0.2 % Gelatin as stabilizer and 0.05 % Sodium Azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    IRAK2
    Alternative Name
    IRAK2 (IRAK2 Antibody Abstract)
    Synonyms
    IRAK-2, 6330415L08Rik, AI649099, interleukin 1 receptor associated kinase 2, interleukin-1 receptor-associated kinase 2, IRAK2, Irak2
    Background
    The binding of interleukin-1 (IL-1) to its receptor IL-1RI initiates a signaling cascade that results in the activation of NF-kB. Recently protein kinases designated IRAKs (IL-1 receptor-associated kinases) have been identified and designated as IRAK-1, IRAK-2 and IRAK-M. IRAK-2 is a serine/threonine protein kinase. The primary amino acid sequence of IRAK-2 shares similarity with that of Pelle, a protein kinase that is essential for the activation of a NF-kB homolog in Drosophila. IRAK (IL-1 receptor kinase) and mediates NF-kB activation by members of IL-1 family including IL-1 and a novel cytokine IL-18. Disruption of IRAK expression by anti-sense oligonucleotides inhibits IL-1 and IL-18-induced activation of NF-kB and activator protein, AP-1.Synonyms: IRAK-2, Interleukin-1 receptor-associated kinase-like 2
    Gene ID
    3656
    NCBI Accession
    NP_001561
    UniProt
    O43187
    Pathways
    TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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