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Galactosamine (N-Acetyl)-6-Sulfate Sulfatase (GALNS) (Internal Region) antibody Primary Antibody

GALNS Reactivity: Human WB Host: Goat Polyclonal unconjugated
Catalog No. ABIN374878
$537.90
Plus shipping costs $45.00
0.1 mg
local_shipping Shipping to: United States
Available
  • Target
    Galactosamine (N-Acetyl)-6-Sulfate Sulfatase (GALNS)
    Binding Specificity
    • 15
    • 9
    • 8
    • 8
    • 8
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 65
    • 9
    • 8
    Human
    Host
    • 60
    • 7
    • 2
    Goat
    Clonality
    • 65
    Polyclonal
    Conjugate
    • 26
    • 8
    • 7
    • 7
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Un-conjugated
    Application
    • 46
    • 37
    • 25
    • 17
    • 16
    • 13
    • 13
    • 12
    • 11
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    C-TTHNLEDHTK LP
    Specificity
    This antibody detects GALNS.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human
    Purification
    Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
    Immunogen
    Peptide from the internal region of the protein sequence according to NP_000503.1 Genename: GALNS
  • Application Notes
    Peptide ELISA: limit dilution 1: 64000. Western blot: 0.01-0.03 μg/mL. Approx 60 kDa band observed in Human Bone Marrow andPlacenta lysates (calculated MW of 58.0 kDa according to NP_000503.1).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • Target
    Galactosamine (N-Acetyl)-6-Sulfate Sulfatase (GALNS)
    Alternative Name
    GALNS (GALNS Antibody Abstract)
    Synonyms
    GALNAC6S, GAS, GalN6S, MPS4A, mFLJ00319, galns, zgc:158385, galactosamine (N-acetyl)-6-sulfatase, galactosamine (N-acetyl)-6-sulfate sulfatase, N-acetylgalactosamine-6-sulfatase, galactosamine (N-acetyl)-6-sulfatase L homeolog, GALNS, Galns, Celly_0425, galns.L, galns
    Background
    GALNS (N-acetylgalactosamine-6-sulfatase) is a lysosomal exohydrolase which catalyzes the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder.Synonyms: Chondroitinase, Chondroitinsulfatase, EC=3.1.6.4, GalNAc6S sulfatase, Galactose-6-sulfate sulfatase, N-acetylgalactosamine-6-sulfatase, N-acetylgalactosamine-6-sulfate sulfatase
    Gene ID
    2588
    NCBI Accession
    NP_000503
    UniProt
    P34059
    Pathways
    Glycosaminoglycan Metabolic Process
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