FTL antibody (Ferritin, Light Polypeptide) (C-Term) Primary Antibody
FTL Reactivity: Cow, Dog, Human, Mouse, Rat EIA, IHC (p), WB Host: Goat Polyclonal
Catalog No. ABIN375068
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- Binding Specificity
- C-Term, Light Chain
- Cow, Dog, Human, Mouse, Rat
- This FTL antibody is un-conjugated
- Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
- C-GEYLFERLTL KHD
- This antibody recognizes FTL.
- Cross-Reactivity (Details)
- Species reactivity (expected):Mouse, Rat, Canine (Dog), Bovine.
Species reactivity (tested):Human.
- Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
- Synthetic peptide (C-GEYLFERLTLKHD) from the C-Terminus of Human FTL (NP_000137.2). Genename: FTL
- Application Notes
- Peptide ELISA: 1/4000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
- For Research Use only
- 0.5 mg/mL
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Sammarco, Ditch, Banerjee, Grabczyk: "Ferritin L and H subunits are differentially regulated on a post-transcriptional level." in: The Journal of biological chemistry, Vol. 283, Issue 8, pp. 4578-87, 2008 (PubMed).
- Sammarco, Ditch, Banerjee, Grabczyk: "Ferritin L and H subunits are differentially regulated on a post-transcriptional level." in: The Journal of biological chemistry, Vol. 283, Issue 8, pp. 4578-87, 2008 (PubMed).
- Alternative Name
- Ferritin Light Chain (FTL) (FTL Antibody Abstract)
- Ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis by sequestering and storing iron in a non-toxic and soluble form. It forms a holoenzyme of ~450 kDa, consisting of 24 subunits of two types, H (heavy, 21 kDa) and L (light, 19 kDa), and is capable of storing up to 4,500 atoms of ferric iron. Depending on the tissue type and physiological status of the cell, the ratio of H to L subunits in ferritin can vary widely. Ferritin is found in the liver, spleen, kidney and heart, with smaller amounts being found in blood. Serum ferritin levels serve as an indicator of the amount of iron stored in the body. Serum ferritin is the most sensitive test for anaemia, and is also used as a marker for restless leg syndrome, hemochromatosis and porphyria. As ferritin is an acute-phase reactant, it is often elevated during infection. Defects in ferritin proteins are associated with several neurodegenerative diseases.Synonyms: Ferritin L subunit
- Molecular Weight
- 20.0 kDa (NP_000137.2).
- Gene ID
- NCBI Accession
- Transition Metal Ion Homeostasis
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