SLC11A1 antibody (Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1) (Middle Region)

Catalog No. ABIN453379

Product Details anti-SLC11A1 Antibody

Target:

SLC11A1

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC11A1 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA), Western Blotting (WB)

Specificity: This antibody recognizes NRAMP1/SLC11A1 (Center).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography on Protein A.

Immunogen: KLH conjugated synthetic peptide selected from the Center region of Human NRAMP1/SLC11A1

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SLC11A1

Target:

SLC11A1

Alternative Name: NRAMP1 (SLC11A1 Antibody Abstract)

Synonyms: SLC11A1, NRAMP1, LSH, NRAMP, Bcg, Itg, Lsh, Nramp1, Ity, Nramp, ity, BCG, solute carrier family 11 member 1 L homeolog, solute carrier family 11 member 1, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1, slc11a1.L, SLC11A1, Slc11a1

Background: NRAMP1, also known as SLC11A1, is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as leprosy and tuberculosis, and inflammatory diseases such as Crohn disease and rheumatoid arthritis. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.Synonyms: LSH, NRAMP, NRAMP-1, Natural resistance-associated macrophage protein 1, SLC11A1

Gene ID: 6556

NCBI Accession: NP_000569

UniProt: P49279

Pathways: Transition Metal Ion Homeostasis, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus