HMGB2 antibody (AA 92-118)

Catalog No. ABIN3031202

Product Details anti-HMGB2 Antibody

Target: HMGB2 (High Mobility Group Box 2 (HMGB2))

Binding Specificity: AA 92-118

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMGB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): Expected species reactivity: Rat, Bovine, Pig

Purification: Purified

Immunogen: A portion of amino acids 92-118 from the human protein was used as the immunogen for this HMGB2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the HMGB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the HMGB2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for HMGB2

Target: HMGB2 (High Mobility Group Box 2 (HMGB2))

Alternative Name: HMGB2 (HMGB2 Products)

Synonyms: HMG2 antibody, C80539 antibody, HMG-2 antibody, Hmg2 antibody, HIGH MOBILITY GROUP BETA 1 antibody, HMG BETA 1 antibody, NFD02 antibody, NFD2 antibody, NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR GROUP D 02 antibody, NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR GROUP D 2 antibody, high mobility group B2 antibody, hmgb2 antibody, hmgb2l antibody, im:6909096 antibody, wu:fa20b02 antibody, zgc:101854 antibody, wu:fb22b10 antibody, wu:fc95d12 antibody, zgc:123215 antibody, high mobility group box 2 antibody, high mobility group box 2 S homeolog antibody, high mobility group B2 antibody, high mobility group box 2b antibody, high mobility group box 2a antibody, HMGB2 antibody, Hmgb2 antibody, hmgb2.S antibody, hmgb2b antibody, hmgb2a antibody

Background: HMGB2 is a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.

UniProt: P26583

Pathways: Cellular Response to Molecule of Bacterial Origin