PCSK7 antibody (AA 692-721)

Catalog No. ABIN3032338

Product Details anti-PCSK7 Antibody

Target: PCSK7 (Proprotein Convertase Subtilisin/kexin Type 7 (PCSK7))

Binding Specificity: AA 692-721

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCSK7 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 692-721 from the human protein was used as the immunogen for this PCSK7 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the PCSK7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the PCSK7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for PCSK7

Target: PCSK7 (Proprotein Convertase Subtilisin/kexin Type 7 (PCSK7))

Alternative Name: PCSK7 (PCSK7 Products)

Synonyms: PC7 antibody, PCSK7 antibody, lpc antibody, pc7 antibody, pc8 antibody, spc7 antibody, MGC115258 antibody, wu:fj05c03 antibody, zgc:158336 antibody, LPC antibody, PC8 antibody, SPC7 antibody, AA959856 antibody, proprotein convertase subtilisin/kexin type 7 antibody, proprotein convertase subtilisin/kexin type 7 L homeolog antibody, PCSK7 antibody, pcsk7.L antibody, pcsk7 antibody, Pcsk7 antibody

Background: The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.

UniProt: Q16549