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KCNMB1 antibody

KCNMB1 Reactivity: Human, Mouse, Rat IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN498565
  • Target See all KCNMB1 Antibodies
    KCNMB1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1))
    Reactivity
    Human, Mouse, Rat
    Host
    • 46
    Rabbit
    Clonality
    • 46
    Polyclonal
    Conjugate
    • 11
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This KCNMB1 antibody is un-conjugated
    Application
    • 21
    • 19
    • 13
    • 13
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody detects endogenous levels of MaxiKbeta protein. (region surrounding Lys119)
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Purity
    > 95 % by SDS-PAGE
    Top Product
    Discover our top product KCNMB1 Primary Antibody
  • Application Notes
    Immunohistochemistry: 1/50 - 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    KCNMB1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 1 (KCNMB1))
    Alternative Name
    KCNMB1 (KCNMB1 Products)
    Synonyms
    KCNMB1 antibody, BKbeta1 antibody, K(VCA)beta antibody, SLO-BETA antibody, hbeta1 antibody, hslo-beta antibody, k(VCA)beta-1 antibody, slo-beta-1 antibody, BKBETA antibody, potassium calcium-activated channel subfamily M regulatory beta subunit 1 antibody, potassium large conductance calcium-activated channel, subfamily M, beta member 1 antibody, KCNMB1 antibody, Kcnmb1 antibody
    Background
    The KCNMB1 gene, located on chromosome 5q34, contains four exons and encodes the 191 amino-acid protein MaxiKbeta subunit 1 (also designated calcium-activated potassium channel beta subunit, BK channel beta subunit, Slo-beta and KVCAbeta). MaxiKbeta subunit 1 consists of two putative transmembrane domains, an extracellular loop containing three consensus sequences for N-linked glycosylation and four cysteine residues that might form disulfide bridges. MaxiKbeta subunit 1, one of four subunits in the MaxiKbeta family, is expressed predominately in smooth muscle tissue but is also found in brain, liver and lymphatic tissues. MaxiKbeta subunit 1 associates with MaxiKalpha to form a calcium-activated potassium channel (also designated MaxiK and BK channel). MaxiKbeta subunit 1 increases the sensitivity of the MaxiKalpha to calcium and voltage. The MaxiKalpha/beta1 channel is the most sensitive of all Maxi channels to calcium. MaxiKbeta plays an important role in vasoregulation by controlling the sensitivity of MaxiK channels to calcium, which leads to the proper amount of arterial relaxation.Synonyms: BK channel beta-1, Calcium-activated potassium channel subunit beta-1, Charybdotoxin receptor subunit beta-1, K VCAbeta-1, Maxi K channel beta-1, Slo-beta-1, subfamily M beta-1
    Molecular Weight
    approx. 30 kDa
    Gene ID
    3779
    NCBI Accession
    NP_004128
    UniProt
    Q16558
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