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GAP43 antibody (Growth Associated Protein 43) Primary Antibody

GAP43 Reactivity: Human, Mouse, Rat IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN498648
$513.70
Plus shipping costs $45.00
0.1 mg
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Available
  • Target
    GAP43
    Reactivity
    • 114
    • 114
    • 107
    • 21
    • 12
    • 12
    • 8
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 101
    • 23
    • 7
    • 2
    • 1
    Rabbit
    Clonality
    • 105
    • 29
    Polyclonal
    Conjugate
    • 85
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This GAP43 antibody is un-conjugated
    Application
    • 73
    • 41
    • 28
    • 26
    • 26
    • 23
    • 23
    • 22
    • 20
    • 18
    • 17
    • 4
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody detects endogenous levels of GAP43 protein. (region surrounding Ala35)
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Purity
    > 95 % by SDS-PAGE
  • Application Notes
    Immunohistochemistry: 1/50 - 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    GAP43
    Alternative Name
    GAP43 (GAP43 Antibody Abstract)
    Synonyms
    B-50, PP46, Basp2, GAP-43, b-50, gap-43, gap43b, pp46, cb310, gap, gap43, gap43a, growth associated protein 43, growth associated protein 43 L homeolog, growth associated protein 43 S homeolog, GAP43, Gap43, gap43.L, gap43, gap43.S
    Background
    GAP-43 (growth associated protein 43, B-50, PP46, calmodulin-binding protein P-57, neuromodulin, neuron growth-associated protein 43, protein F1) is a crucial component for regenerative response in the nervous system that is present at high levels in neuronal growth cones during development and axonal regeneration. GAP-43 is normally produced by neurons during developmental growth and axonal regeneration, but it is also expressed in specific regions of the normal adult nervous system. The neuron-specific ELAV/Hu family member, HuD, interacts with and stabilizes GAP-43 mRNA in developing neurons and leads to increased levels of GAP-43 protein. Heterozygous GAP-43 knockout mice with GAP-43 levels reduced by one-half display significant memory impairments in cued conditioning or on tests of nociceptive or auditory perception.Synonyms: Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, Neuromodulin, PP46
    Molecular Weight
    approx. 38, 43 kDa
    Gene ID
    2596
    NCBI Accession
    NP_002036
    UniProt
    P17677
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