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GUCA1C antibody (AA 141-209) (AbBy Fluor® 750)

GUCA1C Reactivity: Human WB, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 750
Catalog No. ABIN5003270
  • Target See all GUCA1C Antibodies
    GUCA1C (Guanylate Cyclase Activator 1C (GUCA1C))
    Binding Specificity
    • 14
    • 14
    • 7
    • 3
    • 1
    AA 141-209
    Reactivity
    Human
    Host
    • 30
    • 2
    Rabbit
    Clonality
    • 31
    • 1
    Polyclonal
    Conjugate
    • 9
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GUCA1C antibody is conjugated to AbBy Fluor® 750
    Application
    • 32
    • 16
    • 12
    • 12
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GCAP3
    Isotype
    IgG
    Top Product
    Discover our top product GUCA1C Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    GUCA1C (Guanylate Cyclase Activator 1C (GUCA1C))
    Alternative Name
    GCAP3 (GUCA1C Products)
    Synonyms
    gcap3 antibody, GCAP3 antibody, guanylate cyclase activator 1C antibody, guca1c antibody, GUCA1C antibody
    Background

    Synonyms: GCAP 3, Guanylate cyclase activating photoreceptor 3, Guanylate cyclase activator 1C, Guanylyl cyclase activating protein 3, Guanylyl cyclase-activating protein 3, GUC1C_HUMAN, GUCA1C.

    Background: The intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating proteins (GCAP). GCAPs are calcium-binding proteins belonging to the calmodulin superfamily and are specifically expressed in retina. GCAP3 (Guanylyl cyclase-activating protein 3), also known as GUCA1C (Guanylate cyclase activator 1C), is a 209 amino acid EF-hand calcium binding protein that is activated by the decrease in calcium from the absorption of light by rhodopsin. Activation of GCAP3 leads to stimulation of guanylate cyclase 1 and 2 (GC1 and GC2), which increases cGMP concentration. Calcium sensitive regulation of GC is essential in recovery of the rod receptor dark state following light exposure. There are two isoforms of GCAP3 that are produced as a result of alternative splicing events.

    Gene ID
    9626
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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