Organic Solute Transporter beta (OSTBETA) antibody (Alexa Fluor 680) Primary Antibody
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- Target
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Clonality
- Polyclonal
- Conjugate
- Alexa Fluor 680
- Application
- Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human OST-beta
- Isotype
- IgG
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- Application Notes
- IF(IHC-P) 1:50-200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
- Storage
- 4 °C
- Storage Comment
- Store at 4°C
- Expiry Date
- 12 months
-
- Target
- Alternative Name
- OST-beta (OSTBETA Antibody Abstract)
- Synonyms
- Ostb, Ostbeta, RGD1565748, OSTB, OSTBETA, solute carrier family 51, beta subunit, solute carrier family 51 beta subunit, Slc51b, SLC51B
- Background
The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum.
Subcellular location: Extracellular
Synonyms: organic solute transporter beta Ostbeta, Organic solute transporter subunit beta, Ostbeta, Ost beta, OST-beta, OSTB, OSTB_HUMAN.
- Gene ID
- 123264
- Pathways
- Regulation of Carbohydrate Metabolic Process