Vinexin antibody (AA 401-500) (Alexa Fluor 750)

Catalog No. ABIN5012430

Product Details anti-Vinexin Antibody (Alexa Fluor 750)

Target: Vinexin (Sorbs3) (Sorbin and SH3 Domain Containing 3 (Sorbs3))

Binding Specificity: AA 401-500

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Vinexin antibody is conjugated to Alexa Fluor 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Vinexin

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Vinexin

Target: Vinexin (Sorbs3) (Sorbin and SH3 Domain Containing 3 (Sorbs3))

Alternative Name: Vinexin (Sorbs3 Products)

Synonyms: zgc:113031 antibody, si:dkey-162f21.1 antibody, SCAM-1 antibody, SH3P3 antibody, Sh3d4 antibody, vinexin-g antibody, SCAM1 antibody, SH3D4 antibody, sorbin and SH3 domain containing 3 antibody, SORBS3 antibody, sorbs3 antibody, Sorbs3 antibody

Background:

Synonyms: SCAM 1, SCAM1, SH3 containing adapter molecule 1, SH3 domain containing adapter molecule 1, SH3D4, Sorbin and SH3 domain containing 3, Sorbin and SH3 domain containing protein 3, Sorbs3, Vinexin alpha, Vinexin, Vinexin beta (SH3 containing adaptor molecule 1).

Background: Vinexin is a 671 amino acid protein that is expressed as two isoforms, designated Vinexin alpha and Vinexin beta. Localized to cell junctions in both the cytoplasm and the cytoskeleton, Vinexin alpha functions to promote Actin stress fiber formation, playing an important role in modification of the Actin cytoskeleton. Like Vinexin alpha, Vinexin beta is localized to cell junctions in the cytoplasm, but is also found in the nucleus where it plays an important role in cell spreading and in activation of the JNK pathway in response to EGF stimulation. Although Vinexin alpha and Vinexin beta have different roles within the cell, both proteins contain three SH3 domains in their carboxy terminus and are expressed in a variety of tissues, including placenta, heart, liver, brain, pancreas and skeletal muscle. Together, Vinexin alpha and Vinexin beta are involved in cell-cell adhesion, signal transduction and cytoskeletal organization throughout the cell.

Pathways: MAPK Signaling