LRRC32 antibody (Leucine Rich Repeat Containing 32)

Catalog No. ABIN5541855

Product Details anti-LRRC32 Antibody

Target: LRRC32

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Reactivity: Human

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• Human 14
• Mouse 9
• Rat 3
• Monkey 1

Host: Mouse

Clonality: Monoclonal

Conjugate: This LRRC32 antibody is un-conjugated

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• Un-conjugated 11
• FITC 3
• PE 2
• Biotin 1
• HRP 1

Application: Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)

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• ELISA 9
• Western Blotting (WB) 8
• Flow Cytometry (FACS) 7
• Immunohistochemistry (IHC) 6
• Immunocytochemistry (ICC) 3
• Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 2

Specificity: This antibody recognizes GARP / LRRC32, an approximately 80 kDa glycoprotein expressed e.g. on the surface of megakaryocytes, platelets and activated Treg cells.

Purification: Protein-A affinity chromatography

Immunogen: Purified human sGARP protein

Clone: GARP5

Isotype: IgG1

Application Details

Application Notes: Flow cytometry. Immunoprecipitation. Western blot. ELISA.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate buffered saline (PBS) Preservatives: 15 mM sodium azide, approx. pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for LRRC32

Target: LRRC32

Alternative Name: lrrc32,garp (LRRC32 Antibody Abstract)

Synonyms: D11S833E, GARP, AI426318, D11S833Eh, D7H11S833E, EG434215, Garp, leucine rich repeat containing 32, LRRC32, Lrrc32

Background: GARP (glycoprotein A repetitions predominant protein), also known as Garpin or LRRC32 (leucin-rich repeat containing protein 32) is an approximately 80 kDa transmembrane glycoprotein detected on the surface of megakaryocytes, platelets, and activated Treg cells. It binds to the latency-associated peptide (LAP) domain of pro-TGF beta and regulates its storage and activation. The expression of GARP on Treg cells seems to be necessary for their suppressive functions.

UniProt: Q14392

Pathways: Activated T Cell Proliferation