Arrestin 3 antibody (Arrestin, beta 2) (Internal Region)

Details for Product anti-ARRB2 Antibody No. ABIN5553081
Antigen
  • ARRB2
  • arb2
  • arr2
  • arrestin
  • barr2
  • betaarr2
  • ARB2
  • ARR2
  • BARR2
  • BARRES
  • AI326910
  • AW122872
  • arrb2
  • zgc:64007
  • arrestin beta 2
  • arrestin, beta 2
  • arrestin beta 2 L homeolog
  • arrestin, beta 2b
  • ARRB2
  • arrb2
  • Arrb2
  • arrb2.L
  • arrb2b
Alternatives
anti-Human Arrestin 3 antibody for Western Blotting
Epitope
Internal Region
11
6
5
4
4
4
3
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
102
41
37
6
5
5
5
4
3
2
2
1
1
1
1
Host
Goat
70
20
12
Clonality
Polyclonal
Conjugate
This Arrestin 3 antibody is un-conjugated
7
3
2
2
2
2
2
2
2
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
77
54
38
26
16
15
5
1
1
1
1
Options
Immunogen Peptide with sequence from the internal region of the protein sequence according to NP_004304.1, NP_945355.1. Genename: ARRB2
Sequence C-HDHIPLPRPQ S
Specificity This antibody is expected to recognizse both reported isoforms NP_004304.1 and NP_945355.1. No cross-reactivity is expected with Arrestin beta 1.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse, Rat.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Plasmids, Primers & others Plasmids, Primers & others Arrestin 3 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Arrestin beta-2 / ARRB2 (ARRB2 Antibody Abstract)
Background Members of arrestin/beta arrestin protein family are thought to participate in agonist mediated desensitization of G protein coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors.Synonyms: ARB2, ARR2, Beta-arrestin-2
Molecular Weight 46.1 kDa according to NP_004304.1 and 44.4 according to NP_945355.1.
Gene ID 409, 9606
UniProt P32121
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Phototransduction, Thromboxane A2 Receptor Signaling
Application Notes Peptide ELISA: 1/32000. Western Blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Product cited in: Cassidy, Slyne, OKelly, Traynor, Conlon, Johnston, Slattery, Ryan, McMorrow: "Urinary biomarkers of chronic allograft nephropathy." in: Proteomics. Clinical applications, Vol. 9, Issue 5-6, pp. 574-85, 2015 (PubMed).

Montserrat, Ramírez-Bajo, Xia, Sancho-Martinez, Moya-Rull, Miquel-Serra, Yang, Nivet, Cortina, González, Izpisua Belmonte, Campistol: "Generation of induced pluripotent stem cells from human renal proximal tubular cells with only two transcription factors, OCT4 and SOX2." in: The Journal of biological chemistry, Vol. 287, Issue 29, pp. 24131-8, 2012 (PubMed).

Zakrzewicz, Krasteva, Wilhelm, Dietrich, Wilker, Padberg, Wygrecka, Grau: "Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys." in: Immunobiology, Vol. 216, Issue 7, pp. 854-61, 2011 (PubMed).

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