Rab6-GTP (Gln72Leu-Mutant) antibody (Atto 488)

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Fruit Fly (Drosophila melanogaster), Human, Mouse (Murine)
Antibody Type
Recombinant Antibody
Clonality (Clone)
Monoclonal ()
Atto 488
Immunocytochemistry (ICC)
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Immunogen Recombinant Rab6AQ72L, a GTP-locked mutant of Rab6A in which Gln72 is replaced by Leu.
Clone AA2
Isotype IgG2
Specificity Recognizes human, mouse and Drosophila GTP-bound Rab6a and Rab6b and mutant Rab6Q72L.
Cross-Reactivity Fruit Fly (Drosophila melanogaster), Human, Mouse (Murine)
Cross-Reactivity (Details) Does not detect Rab6•GDP.
Purity >95 % (SDS-PAGE)
Background Rab6 is involved in protein transport. It is a regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER).
UniProt P20340

anti-Rab6-GTP, monoclonal antibody (recombinant) (AA2) is composed of human variable regions (VH and VL) (lambda-chain) of immunoglobulin fused to the human lgG2 Fc domain. anti-Rab6-GTP, monoclonal antibody (recombinant) (AA2) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer In PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Short Term Storage: +4°C
Long Term Storage: +4°C
Keep conjugated formats at +4°C. Stable for at least 1 year after receipt when stored at +4°C.
Expiry Date 12 months
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