CLEC2D antibody (AA 1-154)

Catalog No. ABIN565412

Product Details anti-CLEC2D Antibody

Target: CLEC2D (C-Type Lectin Domain Family 2, Member D (CLEC2D))

Binding Specificity: AA 1-154

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CLEC2D antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Mouse monoclonal antibody raised against a full length recombinant CLEC2D.

Sequence: MHDSNNVEKD ITPSELPANP GCVHSKEHSI KATLIWRLFF LIMFLTIIVC GMVAALSAIR ANCHQEPSVC LQAACPESWI GFQRKCFYFS DDTKNWTSSQ RFCDSQDADL AQVESFQELN FLLRYKGPSD HWIGLSREQG QPWKWINGTE WTRQ

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: CLEC2D (AAH19883, 1 a.a. ~ 154 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 4C7

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-CLEC2D antibody (ABIN565412)

Williams, Eaton, Jones, Rengan, Burshtyn: "Vaccinia virus Western Reserve induces rapid surface expression of a host molecule detected by the antibody 4C7 that is distinct from CLEC2D." in: Microbiology and immunology, Vol. 60, Issue 11, pp. 754-769, (2016) (PubMed).

Chalan, Bijzet, Huitema, Kroesen, Brouwer, Boots: "Expression of Lectin-Like Transcript 1, the Ligand for CD161, in Rheumatoid Arthritis." in: PLoS ONE, Vol. 10, Issue 7, pp. e0132436, (2015) (PubMed).

Germain, Meier, Jensen, Knapnougel, Poupon, Lazzari, Neisig, Håkansson, Dong, Wagtmann, Galsgaard, Spee, Braud: "Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-? contributes to modulate immune responses." in: The Journal of biological chemistry, Vol. 286, Issue 44, pp. 37964-75, (2011) (PubMed).

Germain, Bihl, Zahn, Poupon, Dumaurier, Rampanarivo, Padkjær, Spee, Braud: "Characterization of alternatively spliced transcript variants of CLEC2D gene." in: The Journal of biological chemistry, Vol. 285, Issue 46, pp. 36207-15, (2010) (PubMed).

Rosen, Cao, Avery, Tangye, Liu, Houchins, Lanier: "Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 10, pp. 6508-17, (2008) (PubMed).

Roth, Mittelbronn, Wick, Meyermann, Tatagiba, Weller: "Malignant glioma cells counteract antitumor immune responses through expression of lectin-like transcript-1." in: Cancer research, Vol. 67, Issue 8, pp. 3540-4, (2007) (PubMed).

Target Details for CLEC2D

Target: CLEC2D (C-Type Lectin Domain Family 2, Member D (CLEC2D))

Alternative Name: CLEC2D (CLEC2D Products)

Background: Full Gene Name: C-type lectin domain family 2, member D
Synonyms: CLAX,LLT1,OCIL

Gene ID: 29121

Pathways: Regulation of Leukocyte Mediated Immunity