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Topoisomerase I antibody (AA 526-765)

TOP1 Reactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5692844
  • Target See all Topoisomerase I (TOP1) Antibodies
    Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))
    Binding Specificity
    • 11
    • 8
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 526-765
    Reactivity
    • 62
    • 24
    • 14
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 49
    • 11
    • 2
    Rabbit
    Clonality
    • 41
    • 21
    Polyclonal
    Conjugate
    • 35
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This Topoisomerase I antibody is un-conjugated
    Application
    • 38
    • 17
    • 15
    • 13
    • 9
    • 8
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Topoisomerase I detection. Tested with WB, Direct ELISA in Human,Mouse,Rat.
    Immunogen
    E. coli-derived human Topoisomerase I recombinant protein (Position: E526-F765).
    Top Product
    Discover our top product TOP1 Primary Antibody
  • Application Notes

    Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

    Application Details: Western blot, 0.1-0.5 μg/mL
    Direct ELISA, 0.1-0.5 μg/mL

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
  • Target
    Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))
    Alternative Name
    TOP1 (TOP1 Products)
    Target Type
    Viral Protein
    Background

    Synonyms: DNA topoisomerase 1, DNA topoisomerase I, TOP1,

    Tissue Specificity: Endothelial cells.

    Background: DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.

    UniProt
    P11387
    Pathways
    Caspase Cascade in Apoptosis, Stem Cell Maintenance
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