Kallikrein 1 antibody (KLK1) (AA 25-262)

Details for Product anti-KLK1 Antibody No. ABIN5693026
Antigen
  • KLKR
  • Klk6
  • hK1
  • klkr
  • kallikrein
  • 0610007D04Rik
  • Kal
  • Klk1b6
  • mGk-6
  • kallikrein 1
  • kallikrein 1 L homeolog
  • KLK1
  • klk1.L
  • LOC100101620
  • Klk1
Epitope
AA 25-262
15
14
11
9
8
5
4
4
4
4
2
2
2
1
1
1
Reactivity
Human
100
38
28
Host
Rabbit
107
15
13
Clonality
Polyclonal
Conjugate
This Kallikrein 1 antibody is un-conjugated
13
9
6
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
95
58
45
26
13
11
10
7
3
1
Options
Immunogen E. coli-derived human Kallikrein 1 recombinant protein (Position: I25-S262).
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Kallikrein 1 detection. Tested with WB, ELISA(Cap) in Human.
Plasmids, Primers & others Plasmids, Primers & others Kallikrein 1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name KLK1 (KLK1 Antibody Abstract)
Background

Synonyms: Kallikrein-1, Kidney/pancreas/salivary gland kallikrein, Tissue kallikrein, KLK1

Tissue Specificity: Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.

Background: KLK1(KALLIKREIN 1), also called KLKR, is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family. KLK1 is a serine protease that generates Lys-bradykinin by specific proteolysis of kininogen-1. The KLK1 gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19 and its exact cytogenetic location is 19q13.33. The KLK1 gene contains 5 coding exons. And KLK1 is the most centromeric gene in the cluster. Mice lacking tissue kallikrein are unable to generate significant levels of kinins in most tissues and develop cardiovascular abnormalities early in adulthood despite normal blood pressure. The protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.

UniProt P06870
Pathways Complement System
Application Notes

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Application Details: Western blot, 0.1-0.5&mu,g/mL
ELISA(Cap), 1-5&mu,g/mL

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Buffer Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Supplier Images
Image no. 1 for anti-Kallikrein 1 (KLK1) (AA 25-262) antibody (ABIN5693026) Western blot analysis of Kallikrein 1 using anti-Kallikrein 1 antibody . Electroph...
Product cited in: Zhang, Xu, Zhao, Chen: "Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury." in: Oncotarget, Vol. 8, Issue 37, pp. 61385-61392, 2017 (PubMed).

Lin, Lin, Chung, Vonderfecht, Camden, Flodby, Borok, Limesand, Mizushima, Ann: "Dynamic involvement of ATG5 in cellular stress responses." in: Cell death & disease, Vol. 5, pp. e1478, 2014 (PubMed).

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