YWHAZ antibody (Tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, zeta Polypeptide)

Catalog No. ABIN5693157

Product Details anti-YWHAZ Antibody

Target: YWHAZ

See all YWHAZ Antibodies

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This YWHAZ antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Brand: Picoband™

Sequence: LLEKFLIPNA SQAESKVFYL KMKGDYYRYL AEVAAGDDKK GIVDQ

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for 14-3-3 zeta/delta detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Immunogen: A synthetic peptide corresponding to a sequence of human 14-3-3 zeta/delta (LLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQ).

Application Details

Application Notes:

Recommended Detection Systems: Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).

Application Details: Western blot, 0.1-0.5&mu,g/mL
Immunohistochemistry(Paraffin-embedded Section), 0.5-1&mu,g/mL

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Target Details for YWHAZ

Target: YWHAZ

See all YWHAZ Antibodies

Alternative Name: YWHAZ (YWHAZ Antibody Abstract)

Synonyms: 14-3-3-zeta, KCIP-1, YWHAD, 14-3-3zeta, Ywhaz, ACYPI003154, 14-3-3z, kcip-1, ywhaq, 1433z, ywhaz, ywhazb, 1110013I11Rik, AI596267, AL022924, AU020854, ywhaza, fb14h09, wu:fb05g08, wu:fb14h09, ywhai, zgc:55807, 14-3-3, 14-3-3 zeta, 14-3-3ZETA, 14-3-3leo, 2G1, 4-3-3 zeta, 5.11, 549, BEST:GH05075, CG17870, D14-3-3, D14-3-3zeta, Dmel\\CG17870, K, LEO, Leo, PAR-5, PAR5, Par-5, d14-3-3zeta, l(2)07103, l(2)46CFe, l(2)46Ee, leo, par-5, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta, 14-3-3 protein zeta, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta L homeolog, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta S homeolog, 14-3-3 protein zeta/delta pseudogene, CG17870 gene product from transcript CG17870-RE, YWHAZ, 14-3-3zeta, ywhaz, 1433z, ywhaz.L, Ywhaz, ywhaz.S, LOC100855903

Background:

Synonyms: 14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, KCIP-1, YWHAZ

Background: 14-3-3 protein zeta/delta (14-3-3ζ) is a protein that in humans is encoded by the YWHAZ gene on chromosome 8. This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99 % identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.

UniProt: P63104

Pathways: Apoptosis, Hormone Transport, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Membrane, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location