Synonyms: Ca2 activated neutral protease,Calcium activated neutral proteinase,Calcium activated neutral proteinase small subunit,Calcium dependent protease small subunit 1,Calcium dependent protease small subunit,Calcium-activated neutral proteinase 1,Calpain 1,Calpain 1 large subunit,Calpain 1,(mu/I) large subunit,Calpain mu type,Calpain mu-type,Calpain regulatory subunit,Calpain small subunit 1,Calpain,large polypeptide L1,Calpain-1 catalytic subunit,Calpain-1 large subunit,CAN1,CANP 1,CANP,CANP small subunit,CANP1,CANPL 1,CANPL1,CAPN 1,CAPN1,Cell proliferation inducing protein 30,Cell proliferation-inducing gene 30 protein,Micromolar Calpain,Micromolar-calpain,Mu Calpain,muCANP,muCL
Background: The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.