CD40 antibody

Catalog No. ABIN5966697

Product Details anti-CD40 Antibody

Target: CD40

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD40 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human CD40

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CD40

Target: CD40

Alternative Name: CD40 (CD40 Products)

Synonyms: Bp50 antibody, CDW40 antibody, TNFRSF5 antibody, p50 antibody, AI326936 antibody, GP39 antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TRAP antibody, Tnfrsf5 antibody, TNFSF5 antibody, CD40 molecule antibody, CD40 antigen antibody, CD40 antibody, Cd40 antibody

Background:

Synonyms: AI326936,B cell associated molecule CD40,B cell surface antigen CD40,B cell-associated molecule,B-cell surface antigen CD40,Bp50,CD 40,CD40,CD40 antigen (TNF receptor superfamily member 5),CD40 antigen,CD40 Molecule,CD40 Molecule,TNF receptor superfamily member 5,CD40 protein,CD40 type II isoform,CD40L receptor,CDw40,GP39,HIGM1,IGM,IMD3,MGC9013,Nerve growth factor receptor related B lymphocyte activation molecule,OTTHUMP00000031699,OTTHUMP00000031700,p50,T-BAM,TBAM,TNF receptor superfamily member 5,TNFRSF5,TNR5,TRAP,Tumor necrosis factor receptor superfamily,member 5,Tumor necrosis factor receptor superfamily member 5,Tumor necrosis factor receptor superfamily member 5 precursor,Tumor necrosis factor receptor superfamily,member 5,isoform CRA_a

Background: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Molecular Weight:

Observed_MW: 42kDa

Calculated_MW: 22kDa/30kDa

Gene ID: 958

UniProt: P25942

Pathways: NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints