CYP2R1 antibody (AA 252-501)

Catalog No. ABIN6139341

Product Details anti-CYP2R1 Antibody

Target: CYP2R1 (Cytochrome P450, Family 2, Subfamily R, Polypeptide 1 (CYP2R1))

Binding Specificity: AA 252-501

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP2R1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VVYDFLSRLI EKASVNRKPQ LPQHFVDAYL DEMDQGKNDP SSTFSKENLI FSVGELIIAG TETTTNVLRW AILFMALYPN IQGQVQKEID LIMGPNGKPS WDDKCKMPYT EAVLHEVLRF CNIVPLGIFH ATSEDAVVRG YSIPKGTTVI TNLYSVHFDE KYWRDPEVFH PERFLDSSGY FAKKEALVPF SLGRRHCLGE HLARMEMFLF FTALLQRFHL HFPHELVPDL KPRLGMTLQP QPYLICAERR

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 252-501 of human CYP2R1 (NP_078790.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CYP2R1

Target: CYP2R1 (Cytochrome P450, Family 2, Subfamily R, Polypeptide 1 (CYP2R1))

Alternative Name: CYP2R1 (CYP2R1 Products)

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency.,CYP2R1,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Endocrine & Metabolism,Mitochondrial metabolism,Cytochromes,Lipid Metabolism,Cytochromes,Lipases,Drug metabolism,Cardiovascular,Lipids,CYP2R1

Molecular Weight: 57 kDa

Gene ID: 120227

UniProt: Q6VVX0

Pathways: Metabolism of Steroid Hormones and Vitamin D