SF3B3 antibody (AA 948-1217)

Catalog No. ABIN6147668

Product Details anti-SF3B3 Antibody

Target: SF3B3 (Splicing Factor 3b, Subunit 3, 130kDa (SF3B3))

Binding Specificity: AA 948-1217

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SF3B3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: VPAAIAPFQG RVLIGVGKLL RVYDLGKKKL LRKCENKHIA NYISGIQTIG HRVIVSDVQE SFIWVRYKRN ENQLIIFADD TYPRWVTTAS LLDYDTVAGA DKFGNICVVR LPPNTNDEVD EDPTGNKALW DRGLLNGASQ KAEVIMNYHV GETVLSLQKT TLIPGGSESL VYTTLSGGIG ILVPFTSHED HDFFQHVEMH LRSEHPPLCG RDHLSFRSYY FPVKNVIDGD LCEQFNSMEP NKQKNVSEEL DRTPPEVSKK LEDIRTRYAF

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 948-1217 of human SF3B3/SAP130 (NP_036558.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SF3B3

Target: SF3B3 (Splicing Factor 3b, Subunit 3, 130kDa (SF3B3))

Alternative Name: SF3B3 (SF3B3 Products)

Background: This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.,SF3B3,RSE1,SAP130,SF3b130,STAF130,Epigenetics & Nuclear Signaling,Transcription Factors,SF3B3

Molecular Weight: 30 kDa/44 kDa/135 kDa

Gene ID: 23450

UniProt: Q15393