PVRL1 antibody (AA 70-350)

Catalog No. ABIN6219212

Product Details anti-PVRL1 Antibody

Target: PVRL1 (Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1))

Binding Specificity: AA 70-350

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PVRL1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: STNGSKQNVA IYNPSMGVSV LAPYRERVEF LRPSFTDGTI RLSRLELEDE GVYICEFATF PTGNRESQLN LTVMAKPTNW IEGTQAVLRA KKGQDDKVLV ATCTSANGKP PSVVSWETRL KGEAEYQEIR NPNGTVTVIS RYRLVPSREA HQQSLACIVN YHMDRFKESL TLNVQYEPEV TIEGFDGNWY LQRMDVKLTC KADANPPATE YHWTTLNGSL PKGVEAQNRT LFFKGPINYS LAGTYICEAT NPIGTRSGQV EVNITEFPYT PSPPEHGRRA G

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 70-350 of human PVRL1 (NP_002846.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PVRL1

Target: PVRL1 (Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) (PVRL1))

Alternative Name: NECTIN1 (PVRL1 Products)

Background: This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.,NECTIN1,CD111,CLPED1,ED4,HIgR,HV1S,HVEC,OFC7,PRR,PRR1,PVRL1,PVRR,PVRR1,SK-12,nectin-1,Cell Biology & Developmental Biology,Cell Adhesion,Immunology & Inflammation,CD markers,Neuroscience,NECTIN1

Molecular Weight: 39 kDa/50 kDa/57 kDa

Gene ID: 5818

UniProt: Q15223

Pathways: Cell-Cell Junction Organization