LC3A / LC3B antibody
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- Target
- LC3A / LC3B
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Reactivity
- Human, Rat
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- Un-conjugated
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Application
- Western Blotting (WB)
- Clone
- 3E9-E5-C9
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anti-LC3A / LC3B antibody
Reactivity: Mouse, Human, Rat WB, IHC Host: Rabbit Polyclonal unconjugated
anti-LC3A / LC3B (AA 31-121) antibodyReactivity: Mouse IF (cc), IF (p), ELISA, IHC (fro), IHC (p), ICC Host: Rabbit Polyclonal unconjugated
anti-LC3A / LC3B antibodyReactivity: Mouse, Human, Rat IF Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Storage
- 4 °C,-20 °C
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- Target
- LC3A / LC3B
- Alternative Name
- LC3A/B
- Background
- LC3A:Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600). LC3B:Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
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