IFI16 antibody (Interferon, gamma-Inducible Protein 16)

Details for Product anti-IFI16 Antibody No. ABIN6257606
Antigen
  • IFNGIP1
  • PYHIN2
  • IFI16
  • Ifitm3l
  • Ifitml
  • interferon gamma inducible protein 16
  • interferon induced transmembrane protein 2
  • myeloid cell nuclear differentiation antigen-like protein
  • interferon-activable protein 203
  • IFI16
  • Ifitm2
  • LOC100156073
  • LOC488622
  • Ifi16
Reactivity
Human
94
9
3
Host
Rabbit
79
15
Clonality
Polyclonal
Conjugate
This IFI16 antibody is un-conjugated
3
3
3
3
3
3
2
2
2
2
2
2
2
1
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
63
28
23
22
17
13
3
2
2
1
1
1
Options
Immunogen A synthesized peptide
Isotype IgG
Specificity IFI16 Antibody detects endogenous levels of total IFI16
Cross-Reactivity Human
Purification The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Plasmids, Primers & others Plasmids, Primers & others IFI16 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name IFI16 (IFI16 Antibody Abstract)
Background

Description: Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Gene: IFI16

Molecular Weight 88 kDa
Gene ID 3428
UniProt Q16666
Pathways Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Autophagy
Application Notes WB 1:500~1:1000, IF/ICC 1:100-1:500
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20 °C.Stable for 12 months from date of receipt
Expiry Date 12 months
Supplier Images
Image no. 1 for anti-Interferon, gamma-Inducible Protein 16 (IFI16) antibody (ABIN6257606) Western blot analysis of extracts from HeLa cells using IFI16 antibody.
Image no. 2 for anti-Interferon, gamma-Inducible Protein 16 (IFI16) antibody (ABIN6257606) ABIN6275142 staining HeLa cells by IF/ICC. The sample were fixed with PFA and permea...
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