TSH receptor antibody (Thyroid Stimulating Hormone Receptor)

Details for Product anti-TSHR Antibody No. ABIN6297581
Antigen
  • CHNG1
  • LGR3
  • hTSHR-I
  • AI481368
  • hypothroid
  • hyt
  • pet
  • TSHRA
  • TSH-R
  • thyroid stimulating hormone receptor
  • tshr
  • TSHR
  • Tshr
Reactivity
Human
171
71
62
8
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5
3
1
1
Host
Mouse
135
36
7
Clonality
Monoclonal
Conjugate
This TSH receptor antibody is un-conjugated
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7
7
4
4
4
4
4
4
3
3
3
3
3
2
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
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Options
Purpose Mouse anti-Human Thyroid Stimulating Hormone Receptor / TSHR Antibody (alpha chain) [Sodium Azide Free]
Immunogen Recombinant human TSH Receptor alpha chain protein was used as the immunogen for this TSHR antibody.
Specificity Cytoplasmic, cell surface
Purification Recombinant human TSH Receptor alpha chain protein was used as the immunogen for this TSHR antibody.
Plasmids, Primers & others Plasmids, Primers & others TSH receptor products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Thyrotropin receptor (TSHR Antibody Abstract)
Background

Target Description: Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.

Gene Symbol: TSHR///LGR3

Gene ID 7253
UniProt P16473
Pathways Thyroid Hormone Synthesis
Application Notes FACS: 0.5-1 μg/10^6 cells in 0.1ml
IF: 1-2 μg/mL
IHC (FFPE): 1-2 μg/mL
Restrictions For Research Use only
Buffer In 1X PBS, BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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