NK2 Homeobox 1 (NKX2-1) antibody

Details for Product No. ABIN6297615
Antigen
  • BCH
  • BHC
  • NK-2
  • NKX2.1
  • NKX2A
  • TEBP
  • TITF1
  • TTF-1
  • TTF1
  • titf1-A
  • Xnkx-2.1
  • NKX2-1
  • LOC100227803
  • AV026640
  • Nkx2.1
  • T/EBP
  • Titf1
  • Ttf-1
  • nk2.1a
  • nkx2.1
  • nkx2.4a
  • titf1
  • titf1a
  • NK2 homeobox 1
  • NK2 homeobox 1 L homeolog
  • NK2 homeobox 4b
  • NKX2-1
  • nkx2-1.L
  • Nkx2-1
  • nkx2.4b
Reactivity
Human, Mouse (Murine), Rat (Rattus)
212
134
130
2
2
2
2
Host
Mouse
120
96
Clonality
Monoclonal
Conjugate
Un-conjugated
10
7
7
7
7
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
99
96
92
63
57
51
28
12
6
4
3
3
2
1
Options
Purpose Mouse anti-Human/Mouse/Rat TTF1 Antibody [Sodium Azide Free]
Immunogen Recombinant protein was used as the immunogen for the TTF1 antibody.
Specificity Nuclear
Purification Recombinant protein was used as the immunogen for the TTF1 antibody.
Antigen
Alternative Name Homeobox protein Nkx-2.1 (NKX2-1 Antibody Abstract)
Background

Target Description: Recognizes a protein of 40 kDa, identified as Thyroid transcription factor-1. TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

Gene Symbol: NKX2-1///NKX2A///TITF1///TTF1

Gene ID 7080
UniProt P43699
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Glucan Metabolic Process, Feeding Behaviour
Application Notes Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)
Restrictions For Research Use only
Buffer In 1X PBS, BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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