CD53 antibody
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- Target See all CD53 Antibodies
- CD53
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD53 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)
- Purpose
- Mouse anti-Human CD53 Antibody [Sodium Azide Free]
- Specificity
- Cell surface
- Purification
- Stimulated human leukocytes were used as the immunogen for the CD53 antibody.
- Immunogen
- Stimulated human leukocytes were used as the immunogen for the CD53 antibody.
- Top Product
- Discover our top product CD53 Primary Antibody
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- Application Notes
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Functional Activity (Order SAF formulation)
Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL - Restrictions
- For Research Use only
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- Buffer
- In 1X PBS, BSA free, sodium azide free
- Preservative
- Azide free
- Storage
- 4 °C,-20 °C
- Storage Comment
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Target
- CD53
- Alternative Name
- Leukocyte surface antigen CD53 (CD53 Products)
- Synonyms
- AI323659 antibody, Ox-44 antibody, Tspan25 antibody, MOX44 antibody, TSPAN25 antibody, OX44 antibody, CD53 antigen antibody, CD53 molecule antibody, Cd53 molecule antibody, Cd53 antibody, CD53 antibody
- Background
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Target Description: Recognizes a protein of 33-55 kDa, identified as CD53 (Workshop VI, Code N-L033). It is expressed on monocytes and macrophages, dendritic cells, osteoblasts and osteoclasts, and on T and B cells from every stage of differentiation but is absent from platelets, red blood cells. CD53 appears to be the marker with widest reactivity as well as the marker with the strictest specificity to hematopoietic cells. CD53 is a type III membrane with both termini in the cytoplasm and two loops in the extracellular environment. This molecule, in common with other members of tetraspan family, is involved in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. CD53 crosslinking induces calcium flux on human monocyte and B cells. Cross-linking of CD53 promotes activation of resting human B-lymphocytes. This mAb recognizes CD53 transfected cells and partially inhibits T-cell proliferation induced by CD3 antibody (clone: UCHT1).
Gene Symbol: CD53///MOX44///TSPAN25
- Gene ID
- 963
- UniProt
- P19397
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